疟原虫与肿瘤关系的研究进展  

Research advance on the relationship between plasmodium and tumor

作　　者：张欣 顾思逸 陈晴晴 程银祥 张方方[3] ZHANG Xin;GU Siji;CHEN Qingqing;CHENG Yinxiang;ZHANG Fangfang(Department of Clinical Medicine , Xuzhou Medical University , Xuzhou 2210Q4, China;Department of Clinical Medicine Benghu Medical College,Benghu 233030, China;Department of Ultrasound, Xuzhou Cancer Hospital, Xuzhou 221000, China)

机构地区：[1]徐州医科大学临床医学系,江苏徐州221004 [2]蚌埠医学院临床医学系,安徽蚌埠233030 [3]徐州市肿瘤医院超声科,江苏徐州221000

出　　处：《中国肿瘤外科杂志》2019年第5期381-385,共5页Chinese Journal of Surgical Oncology

基　　金：大学生创业创新训练计划项目(201810313063X);徐州医科大学“挑战杯/创青春”重点培育项目(18ZK09);江苏高校品牌专业建设工程一期项目(PPZY2015B161)

摘　　要：传统观点认为疟原虫感染会导致疟疾,严重危害人类健康.但随着研究的进展,科学家们发现疟原虫感染与肿瘤也有着重要的相关性.一方面,疟原虫感染促进了Burkitt淋巴瘤的发生发展;另一方面,疟原虫与一些癌症(如胃癌、乳腺癌、肺癌)的死亡率呈负相关.目前,疟原虫感染后对肿瘤的影响机制尚未清楚,可能与天然免疫和适应性免疫有关,具体还需进一步研究.肿瘤作为一种严重疾病,目前尚无有效的治疗手段.而疟原虫免疫疗法的提出将为肿瘤治疗提供新的方向,尤其在肿瘤药物的研发和疫苗的设计方面.作者就疟原虫与肿瘤关系的研究进展进行综述.Traditional belief that malaria infection can lead to malaria, serious harm to human health. But with the progress of research, scientists have found that Plasmodium infection also has an important correlation with tumors. On the one hand, Plasmodium infection promotes the development of Burkitt lymphoma;on the other hand, Plasmodium has a negative relationship with mortality from some cancers such as gastric, breast, and lung cancer. At present, the mechanism of the influence of Plasmodium infection on tumor is not clear, which may be related to the regulation of innate immunity and adaptive immunity, which requires further study by scientists. Tumor as a serious disease, there is no effective treatment. The proposal of Plasmodium malaria immunotherapy will provide a new direction for tumor therapy, especially in the development of tumor drugs and vaccine design. In this paper, the research progress of the relationship between Plasmodium and tumor is reviewed in order to explore new methods of tumor treatment.

关 键 词：疟原虫 肿瘤 关系 

分 类 号：R531.3[医药卫生—内科学]