翼状胬肉切除术联合角膜缘干细胞移植术治疗翼状胬肉的临床疗效刍议  

Clinical Efficacy of Pterygium Excision Combined with Limbal Stem Cell Transplantation in the Treatment of Pterygium

作　　者：张琼[1] 张翠丽[1] 陈宝文[1] 汪鹏[1] ZHANG Qiong;ZHANG Cui-li;CHEN Bao-wen;WANG Peng(Department of Ophthalmology,Peixian County People's Hospital,Peixian,Jiangsu Province,221600 China)

机构地区：[1]沛县人民医院眼科

出　　处：《中外医疗》2019年第26期76-78,共3页China & Foreign Medical Treatment

摘　　要：目的探讨观察翼状胬肉切除术联合角膜缘干细胞移植术治疗翼状胬肉的临床疗效,旨在提高翼状胬肉临床治疗效率。方法方便选择该院2015年1月—2019年3月期间收治的52例翼状胬肉患者作为对象,根据随机数表法按照1∶1比例将其分成两组,其中一组设为对照组,另一组设为研究组,每组26例。对照组,单纯行翼状胬肉切除术,研究组,翼状胬肉切除术+角膜缘干细胞移植术治疗,观察评价两组患者的临床疗效。结果①治疗后,研究组BUT及UCVA指标高于对照组[(11.59±4.82)svs(10.24±3.45)s;(0.59±0.14)vs(0.51±0.23)],差异有统计学意义(t=4.591、6.781,P<0.05);②治疗后,研究组CAD、t-HOA以及上皮修复时间比对照组小[(0.84±0.32)vs(1.27±0.89);(0.32±0.18)vs(0.45±0.13);(5.34±0.56)dvs(7.56±0.39)d],数据分析,差异有统计学意义(t=4.084、5.698、8.375,P<0.05);③统计显示,研究组2例并发症,对照组3例并发症,发生率比较(7.6%vs11.5%),差异无统计学意义(χ^2=0.880,P=0.348);④随访发现,研究组1例复发,对照组6例复发,研究组复发率低于对照组(3.8%vs23.1%)(χ^2=15.999,P=0.000)。结论翼状胬肉切除术联合角膜缘干细胞移植术治疗翼状胬肉,疗效显著,安全可靠。Objective To investigate the clinical efficacy of pterygium excision combined with limbal stem cell transplantation in the treatment of pterygium,in order to improve the clinical efficacy of pterygium.Methods Convenient selected 52 patients with pterygium admitted to our hospital from January 2015 to March 2019 were selected as subjects.According to the random number table method,they were divided into two groups according to the 1:1 ratio.The other group was set as the study group,with 26 cases in each group.In the control group,pterygium excision was performed alone,the study group,pterygium excision+limbal stem cell transplantation,and the clinical efficacy of the two groups was evaluated.Results 1.After treatment,the BUT and UCVA indexes in the study group were higher than those in the control group[(11.59±4.82)s vs(10.24±3.45)s];(0.59±0.14)vs(0.51±0.23).The difference was statistically significant(t=4.591,6.781,P<0.05);2.After treatment,the study group's CAD,t-HOA and epithelial repair time were smaller than the control group[(0.84±0.32)vs(1.27±0.89);(0.32±0.18)vs(0.45±0.13);(5.34±0.56)d vs(7.56±0.39)d],the difference was statistically significant(t=4.084,5.698,8.375,P<0.05);3.statistics showed that 2 cases of complications in the study group and 3 cases in the control group,the incidence rate was compared(7.6%vs 11.5%),no statistical significance(χ^2=0.880,P=0.348);4.follow-up found that 1 case recurred in the study group,6 cases in the control group recurred,the recurrence rate of the study group was lower than the control group(3.8%vs 23.1%)(χ^2=15.999,P=0.000).Conclusion The treatment of pterygium with pterygium resection combined with limbal stem cell transplantation is effective and safe.

关 键 词：翼状胬肉切除术 角膜缘干细胞移植术 翼状胬肉 并发症 复发 

分 类 号：R5[医药卫生—内科学]