地佐辛联合小剂量右美托咪定(Dex)辅助全身麻醉用于功能性鼻内镜鼻窦手术的临床效果分析  

Clinical Analysis of Dextrozine Combined with Low-dose Dexmedetomidine (Dex) Assisted General Anesthesia for Functional Endoscopic Sinus Surgery

作　　者：钱美娟 崔晓莉 王芸 QIAN Mei-juan;CUI Xiao-li;WANG Yun(Rugao Boai Hospital,Nantong,Jiangsu Province,226500 China)

机构地区：[1]南通市如皋博爱医院

出　　处：《中外医疗》2019年第26期120-123,共4页China & Foreign Medical Treatment

摘　　要：目的分析在功能性鼻内镜鼻窦手术过程中应用地佐辛联合小剂量右美托咪定辅助全身麻醉的临床价值。方法方便选择2018年1月—2019年2月期间入该院就诊接受功能性鼻内镜鼻窦手术治疗患者70例,按照随机数字表法将其分为A组(35例)及B组(35例),分别采取单纯全身麻醉方案,联合使用地佐辛、小剂量右美托咪定及全身麻醉方案,设麻醉诱导插管前为T1、插管时为T2、插管后5min为T3,分析组间临床效果差异。结果A组T1心率(81.25±8.33)次/min、MAP(86.74±11.02)mmHg均与B组的(80.54±8.25)次/min、(86.54±9.28)mmHg间比较差异无统计学意义(心率:t=0.3583,P=0.7212;MAP:t=0.0822,P=0.9348);T2心率(87.98±5.31)次/min、MAP(102.05±12.86)mmHg均显著高于B组的(78.25±5.18)次/min、(84.48±10.73)mmHg(心率:t=7.7598,P=0.0000;MAP:t=6.2063,P=0.0000),T3心率(95.74±6.31)次/min、MAP(95.63±11.52)mmHg均显著高于B组的(77.33±6.17)次/min、(84.68±9.75)mmHg(心率:t=12.3413,P=0.0000;MAP:t=4.2924,P=0.0001);A组组内T1、T2、T3心率及MAP水平间差异有统计学意义(T1vsT2:心率t=4.0305、P=0.0001,MAPt=5.3481、P=0.0000;T1vsT3:心率t=8.2032、P=0.0000,MAPt=3.2991、P=0.0015;T2vsT3:心率t=5.5668、P=0.0000,MAPt=2.1999、P=0.0312);B组内T1、T2、T3心率及MAP水平间差异无统计学意义(T1vsT2:心率t=1.3907、P=0.1688,MAPt=0.8591、P=0.3933;T1vsT3:心率t=1.8434、P=0.0696,MAPt=0.8175、P=0.4165;T2vsT3:心率t=0.6756、P=0.5016,MAPt=0.0816、P=0.9353);B组呛咳发生率5.71%显著低于A组的28.57%(χ^2=6.4368,P=0.0112);B组术后躁动评分(2.24±0.58)分显著低于A组的(3.84±0.95)分(t=8.5042,P=0.0000);B组术后HAMA及HAMD评分显著低于A组及术前(HAMA:A组术前与术后比较t=16.5541、P=0.0000,B组术前与术后比较t=24.7079、P=0.0000,A组与B组术前比较t=0.5858、P=0.5600,A组与B组术后比较t=9.8609、P=0.0000;HAMD:A组术前与术后比较t=18.8016、P=0.0000,B组术前与术后比较t=17.7100、P=0.0000,A组与B组术前比较t=0.4554�Objective To analyze the clinical value of dextrozine combined with low-dose dexmedetomidine in the treatment of general anesthesia during functional endoscopic sinus surgery.Methods A total of 70 patients who underwent functional endoscopic sinus surgery during the period from January 2018 to February 2019 were conveniently selected in the study.They were divided into group A(35 cases)and group B(35 cases)according to the random number table method,a simple general anesthesia program,combined with dextrozine,low-dose dexmedetomidine and general anesthesia,T1 after anesthesia induction,T2 after intubation,T3 after intubation,5 minutes after intubation,analysis Differences in clinical outcomes between groups.Results There was no statistically significant difference in T1 heart rate(81.25±8.33)times/min and MAP(86.74±11.02)mmHg between group A and(80.54±8.25)times/min and(86.54±9.28)mmHg in group B(heart rate:t=0.358 3,P=0.721 2;MAP:t=0.082 2,P=0.934 8);T2 heart rate(87.98±5.31)times/min,MAP(102.05±12.86)mmHg were significantly higher than(78.25±5.18)times/min of group B,(84.48±10.73)mmHg(heart rate:t=7.759 8,P=0.000 0;MAP:t=6.206 3,P=0.000 0),T3 heart rate(95.74±6.31)times/min,MAP(95.63±11.52)mmHg,significantly higher than group B(77.33±6.17)times/min,(84.68±9.75)mmHg(heart rate:t=12.341 3,P=0.000 0;MAP:t=4.292 4,P=0.000 1);T1,T2 in group A There was a statistically significant difference between T3 heart rate and MAP level(T1vsT2:heart rate t=4.030 5,P=0.000 1,MAPt=5.348 1,P=0.000 0;T1vsT3:heart rate t=8.203 2,P=0.000 0,MAPt=3.299 1,P=0.001 5;T2vsT3:heart rate t=5.566 8,P=0.000 0,MAPt=2.199 9,P=0.031 2);there was no statistically significant difference between T1,T2,T3 heart rate and MAP level in group B(T1vsT2:heart rate t=1.390 7,P=0.168 8,MAPt=0.859 1,P=0.393 3;T1vsT3:heart rate t=1.843 4,P=0.069 6,MAPt=0.817 5,P=0.416 5;T2vsT3:heart rate t=0.675 6,P=0.501 6,MAPt=0.081 6,P=0.935 3);the incidence of cough in group B was 5.71%significantly lower than group A of 28.57%(χ^2=6.436 8,P=0.011 2);postoper

关 键 词：功能性鼻内镜鼻窦手术 地佐辛 小剂量右美托咪定 全身麻醉 

分 类 号：R614[医药卫生—麻醉学]