多囊卵巢综合征的易感基因分析  

Susceptibility Gene Analysis of Polycystic Ovary Syndrome

作　　者：张婕 桂娟 徐天星 徐望明[1] ZHANG Jie;GUI Juan;XU Tianxing;XU Wangming(Department of Reproductive Center,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院生殖医学中心

出　　处：《医学综述》2019年第19期3751-3755,共5页Medical Recapitulate

基　　金：国家自然科学基金(81601248)

摘　　要：多囊卵巢综合征(PCOS)是育龄妇女常见的内分泌异常性疾病,与遗传因素、胎儿期暴露在某些危险因素下以及生活方式等相关。PCOS的发病机制尚未完全阐明,病因尚不清楚,但PCOS具有家族聚集性并与多基因遗传相关。近年来,全基因组广泛关联研究揭示了PCOS的遗传可能性,筛选和证实了PCOS的部分易感基因,并预测了PCOS新的风险基因和热点基因。这将有助于阐明PCOS的遗传发病机制,为PCOS的诊断和治疗提供新的研究方向。Polycystic ovary syndrome(PCOS) is the most common endocrine disorder,which is related to genetic factors,fetal exposure to certain risk factors and lifestyle,etc.The pathogenesis and causes of PCOS has not been fully elucidated.But PCOS has family aggregation feature and is associated with polygenic inheritance.In recent years,genome-wide association studies has revealed the genetic possibility of PCOS,screened and confirmed some susceptible genes of PCOS,and predicted new risk genes and hot genes of PCOS,which will help clarify the genetic pathogenesis of PCOS and may provide new research directions for the diagnosis and treatment of PCOS.

关 键 词：多囊卵巢综合征 易感基因 全基因组广泛关联研究 

分 类 号：R711.75[医药卫生—妇产科学]