土家药大泽兰化学成分的分离鉴定  

Isolation and Identification of Chemical Constituents in Tujia Medicine Eupatorium Japonicum

作　　者：刘玲玲 郭洪伟 刘一涵[1] 田云刚[1] 田兰 田华咏 李思迪 盛益华 魏华[1,3] Liu Lingling;Guo Hongwei;Liu Yihang;Tian Yungang;Tian Lan;Tian Huayong;Li Sidi;Sheng Yihua;Wei Hua(College of Biotic Resource and Environmental Science, Jishou University, Hunan Jishou 416000, China;Ethnic Minority TraditionalMedicine Institute of Xiangxi;Tujia Medicine Research Center in Hunan)

机构地区：[1]吉首大学生物资源与环境科学学院,湖南吉首416000 [2]湘西自治州民族医药研究所 [3]湖南省土家医药研究中心

出　　处：《中国药师》2019年第10期1780-1782,1804,共4页China Pharmacist

基　　金：国家自然科学基金青年科学基金项目(编号:81403088);湖南省重点学科建设项目(编号:JSU0713);湖南省土家医药研究中心开放项目(编号:20172001);中医药行业科研专项资助项目(编号:201507002);吉首大学校级自然科学类科研项目(编号:Jdx17024)

摘　　要：目的:研究土家药大泽兰所含的化学成分。方法:采用多种柱色谱方法对大泽兰乙醇提取物的化学成分进行分离,并通过波谱分析和文献对比进行结构鉴定。结果:分离得到7个化合物,分别鉴定为蒲公英甾醇乙酸酯(1)、豆甾醇(2)、9-angeloyloxythymol(3)、9-acetoxythymol 3-O-tiglate(4)、邻羟基苯丙酸(5)、7-hydroxy-4-methyl isochroman-1-one(6)、香豆素(7)。结论:化合物5~7为首次从泽兰属植物中分离得到,化合物1~7均为首次从该植物中分离得到。Objective: To investigate the chemical constituents in Eupatorium japonicum. Methods: Various chromatographic methods were used to isolate and purify the chemical constituents in Eupatorium japonicum,and the structures were identified by spectral analysis and literature comparison. Results: Seven compounds were obtained and their structures were identified as taraxasterol acetate( 1),stigmasterol( 2),9-angeloyloxythymol( 3),9-acetoxythymol 3-O-tiglate( 4),hydrocoumaric acid( 5),7-hydroxy-4-methyl isochroman-1-one( 6) and coumarin( 7). Conclusion: Compounds 5-7 were isolated from Eupatorium genus for the first time,and compounds 1-7 were isolated from the plant for the first time.

关 键 词：土家药 大泽兰 化学成分 分离 鉴定 

分 类 号：R284.1[医药卫生—中药学]