琥珀酸美托洛尔对急性心肌梗死后室性心律失常的效果研究  

Effect of metoprolol succinate on ventricular arrhythmia after acute myocardial infarction

作　　者：周林丽[1] 陈浩[1] 邱樑 Zhou Linli;Chen Hao;Qiu Liang(Shengzhou People' s Hospital of Zhejiang Province (Shengzhou Branch, First Court of Zhejiang University) Medical Section,Shengzhou, Zhejiang, 312400, China)

机构地区：[1]浙江省嵊州市人民医院(浙大一院嵊州分院)医务科

出　　处：《当代医学》2019年第30期61-63,共3页Contemporary Medicine

摘　　要：目的研究琥珀酸美托洛尔对急性心肌梗死后室性心律失常的效果,为患者的治疗及疗效评估提供临床指导。方法选取2017年6月至2018年6月接诊的80例患者为研究对象。按照随机数表法,随机均分为研究组和对照组。对照组采用常规阿司匹林等药物进行治疗,研究组在常规治疗基础上,联合应用琥珀酸美托洛尔进行治疗。治疗前后,比较分析两组患者的心率及心电图状况[QT离散度(QTd)及校正QT离散度(QTcd)],并对患者的疗效及预后进行分析。结果研究组治疗的总有效率(97.50%)显著高于对照组(80.00%;χ^2=4.507,P=0.034)。治疗前,两组患者的心率、QTd及QTcd比较差异无统计学意义;治疗后,两组患者的心率、QTd及QTcd均明显降低(P<0.05),且研究组明显低于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论琥珀酸美托洛尔治疗急性心肌梗死后室性心律失常,疗效显著,能明显改善患者心率心电图状况,值得推广应用。Objective To study the effect of metoprolol succinate on ventricular arrhythmia after acute myocardial infarction, and to provide clinical guidance for the treatment and efficacy evaluation of patients. Methods 80 patients from June 2017 to June 2018 were selected for the study. According to the random number table method, they were randomly divided into study group and control group. The control group was treated with routine aspirin and other drugs, while the study group was treated with metoprolol succinate on the basis of routine treatment. Before and after treatment, the heart rate and electrocardiogram (QTd and corrected QTcd) of the two groups were compared and analyzed, and the curative effect and prognosis of the two groups were analyzed. Results The total effective rate of the study group (97.50%) was significantly higher than that of the control group (80.00%,χ2=4.507, P=0.034). Before treatment, there was no significant difference in heart rate, QTd and QTcd between the two groups;After treatment, the heart rate, QTd and QTcd of the two groups were significantly decreased (P<0.05), and the study group was significantly lower than the control group (P<0.05). There were no significant difference in the incidence of adverse reactions between the two groups. Conclusion Metoprolol succinate is effective in treating ventricular arrhythmia after acute myocardial infarction. It can significantly improve the heart rate and electrocardiogram of patients, and is worthy of wide application.

关 键 词：急性心肌梗死 室性心律失常 琥珀酸美托洛尔 疗效 心电图 

分 类 号：R542.22[医药卫生—心血管疾病] R541.7[医药卫生—内科学]