耐碳青霉烯类肺炎克雷伯菌耐药机制的研究进展  

Advances in research on resistance mechanism of carbapenem-resistant Klebsiella pneumoniae

作　　者：刘晓敏[1] 邰文琳[2] Liu Xiaomin;Tai Wenlin(Department of Clinical Laboratory Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming,Yunnan 650021,China;Department of Clinical Laboratory N0.2 Affiliated Hospital of Kunming Medical University,Kunming, Yunnan 650021,China)

机构地区：[1]云南省中医医院检验科,云南昆明650021 [2]昆明医科大学第二附属医院检验科,云南昆明650021

出　　处：《医药前沿》2019年第26期11-13,共3页Journal of Frontiers of Medicine

摘　　要：耐碳青霉烯类肺炎克雷伯菌是临床治疗和医院感染控制中的困难所在,在世界范围广泛流行.大量研究表明CRKP的耐药机制是多因素联合作用的结果.最主要机制有以下几种:产碳青霉烯酶、β内酰胺酶或AmpC酶联合孔膜蛋白缺失或低表达、主动外排机制以及生物被膜形成等多因素联合的耐药机制.而产碳青霉烯酶是最主要的机制.本文针对CRKP的病死率、感染相关因素、耐药机制进行综述,为CRKP耐药机制研究提供相关参考.Carbapenem-resistant Klebsiella pneumoniae is a difficult problem in clinical treatment and hospital infection control and is widely prevalent throughout the world. Numerous studies have shown that the resistance mechanism of CRKP is the result of a combination of multiple factors. The main mechanisms are as follows:carbapenemase, beta lactamase or AmpC enzyme combined with pore membrane protein deletion or low expression, active efflux mechanism, and biofilm formation and other multi-factor resistance mechanisms. Carbapenemase is the most important mechanism. This article reviews the mortality and infection-related factors of CRKP and the development of drug-resistant machines, and provides reference for the study of CRKP resistance mechanism.

关 键 词：碳青霉烯酶 耐药机制 克雷伯菌 

分 类 号：R563[医药卫生—呼吸系统]