右美托咪定对肝叶切除患者细胞因子及肝功能的影响  

Effects of dexmedetomidine on cytokines and liver function in patients undergoing hepatectomy

作　　者：周世凤 边成富 Zhou Shifeng;Bian Chengfu(Department of Anesthesia,no.2 People's Hospital of Liangshan Yi Autonomous Prefecture, Liangshan,Sichuan 615000,China)

机构地区：[1]凉山彝族自治州第二人民医院麻醉科,四川凉山615000

出　　处：《医药前沿》2019年第26期32-33,共2页Journal of Frontiers of Medicine

摘　　要：目的:观察在手术中使用右美托咪定对肝叶切除患者的肝功能、血浆细胞因子水平的影响.方法:采用随机数字表法将在我院接受治疗的40例肝叶切除患者分为两组.实验组患者注射右美托咪定,时间为10min,剂量为1μg/kg·h,随后以0.5μg/kg·h持续注射;给对照组患者用0.9%的NaCl溶液等量注射.观察这两组患者在不同时间段的肝功能指标及血浆细胞因子变化.结果:两组患者在T0期,ALT和AST无显著差异.随着时间的延长,两组均显著升高,但对照组升高幅度大于观察组,差异显著(P<0.05);两组患者在试验初期,TNF-α和IL-10无差异,随着时间的延长,两组均显著升高,但对照组升高幅度大于观察组,差异显著(P<0.05).结论:右美托咪定可以抑制肝功能损伤和细胞因子的释放,有利于避免缺血再灌注损伤.Objective To study the effects of liver function and plasma cytokine levels in patients with hepatectomy after using dextrometadine during surgery Methods 40 patients with hepatectomy who were treated in our hospital were randomly divided into two groups. In the test group,each patient was injected with dextomidine. The dose is 1μg/ kg ? h, followed continuous injection by 0.5 μg / kg?h;The control group was given 0.9 % of the Nacl solution.Then observed the liver function indexes and plasma cytokines. Results There was no significant difference between AET and AST in T0 of two groups.As time goes by,the datas increased significantly and the control group increased significantly(P<0.05). At first of the trial,there was no difference between TNF-α and IL-10 in the 2 groups.As time goes by,both datas increased significantly,and the control group increased more significantly (P<0.05). Conclusion Dexmedetomidine hydrochloride injection can inhibit liver function injury and release of cytokines,which is beneficial to reduce ischemic reperfusion injury.

关 键 词：右美托咪定 肝功能 细胞因子 

分 类 号：R614[医药卫生—麻醉学]