参黄灌肠方对脓毒症急性胃肠损伤的疗效观察  

The effect of Shenhuang enema prescription on acute gastrointestinal injury due to sepsis

作　　者：张庆[1] 蔡阳平[1] 王兰[1] 刘红栓[1] 李硕 寇男 吴京秦 Zhang Qing;Cai Yangping;Wang Lan;Liu Hongshuan;Li Shuo;Kou Nan;Wu Jingqin(Tongzhou Campus of Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 101100;Dongzhimen Hospital of Beijing University of Chinese Medicine)

机构地区：[1]北京中医药大学东直门医院通州院区

出　　处：《现代中医临床》2019年第5期1-5,共5页Modern Chinese Clinical Medicine

基　　金：北京市通州区卫生发展科研专项项目(No.TF-2017-PT-01-57)

摘　　要：目的探讨参黄灌肠方汤剂保留灌肠治疗脓毒症气虚腑实型急性胃肠损伤的有效性。方法采用随机数字表法将符合纳入排除标准的140例脓毒症气虚腑实型急性胃肠损伤患者分为2组,每组各70例。治疗组给予基础治疗联合参黄灌肠方保留灌肠,对照组给予基础治疗加甘油灌肠剂保留灌肠,每日1次,每次保留灌肠120min,疗程均为6d。观察记录治疗前1天、治疗第3天、停药第1天、停药第4天,患者急性胃肠损伤分级、腹围、急性生理学及慢性健康状况评分系统Ⅱ评分(APACHEⅡ评分)、肠鸣音变化情况。结果治疗组急性胃肠损伤分级下降趋势在治疗第3天(P<0.05)以及停药第1和第4天(P<0.01)都明显优于对照组,肠鸣音在各观察时间段都较对照组好转(P<0.05)。结论参黄灌肠方在降低脓毒症气虚腑实型急性胃肠损伤分级方面具有辅助治疗作用。Objective To explore the effect of Shenhuang enema prescription on acute gastrointestinal injury due to sepsis. Methods A randomized digital table was used to classify 140 patients with acute gastrointestinal injury with stagnation of qi deficiency and stagnation, including 70 patients in each group. The treatment group was given basic treatment combined with Shenhuang enema retention enema, while the control group was given basic treatment plus glycerin enema retention enema, once a day, and the enema was kept for 120 min each time, the course of treatment was 6 days. The changes of patient’s acute gastrointestinal injury grading, abdominal circumference, acute physiology and chronic health status scoring system(APACHE II score), and bowel sounds were recorded 1 day before treatment, 3 days after treatment, 1 day after drug withdrawal, and 4 days after drug withdrawal. Results The grading trend of acute gastrointestinal injury in the treatment group was significantly better than that of the control group on the third day of treatment(P<0.05) and on the first and fourth days of discontinuation(P<0.01). The bowel sounds were compared in each observation period. The control group improved(P<0.05). Conclusion Shenhuang enema has an adjuvant therapeutic effect in reducing the classification of acute gastrointestinal injury with stagnation of qi deficiency and stagnation.

关 键 词：脓毒症 急性胃肠损伤 益气通腑 参黄灌肠方 

分 类 号：R278[医药卫生—中医学]