AECOPD患者抗菌药物应用回顾性分析  

Retrospective analysis of the antibacterials usage in patients with AECOPD

作　　者：许璕[1] 张颖[1] 屈伟[1] 陈志高[1] XU Xun;ZHANG Ying;QU Wei;CHEN Zhigao(Dept.of Pharmacy,Jiangyin Hospital Affiliated to Medical College of SoutheastUniversity,Jiangyin,Jiangsu 214400,China)

机构地区：[1]东南大学医学院附属江阴医院药学部

出　　处：《现代医药卫生》2019年第20期3111-3113,3116,共4页Journal of Modern Medicine & Health

基　　金：黎介寿院士肠道屏障研究专项基金项目（LJS-201811C）

摘　　要：目的分析慢性阻塞性肺疾病急性加重期(AECOPD)住院患者抗菌药物使用情况,为合理用药和临床药师开展药学服务工作提供依据和参考。方法分析该院2016年1-3月收治的100例AECOPD住院患者病历数据资料,包括病原菌分布、药敏实验检测结果、抗菌药物使用情况,计算抗菌药物使用频度(DDDs)、药物利用指数(DUI)及抗菌药物日治疗费用(DDC)。结果100例住院患者抗菌药物使用率为99.00%,涉及7大类12种抗菌药物,构成比最高为喹诺酮类(37.37%),其次为头孢菌素类及其与β-内酰胺抑制剂复合制剂(27.37%)。抗菌药物用药疗程1~33d,平均(7.77±4.55)d。DDDs排位前3位依次是左氧氟沙星、头孢地嗪、头孢西丁;DDC排序后3位依次是莫西沙星、左氧氟沙星和阿奇霉素。结论该院AECOPD患者抗菌药物使用以喹诺酮类和β-内酰胺类为主。抗感染药物使用基本合理,但仍存在个别不合理使用情况,需加强监管。Objective To analyze the usage of antibiotics in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),so as to provide evidence for rational drug usage and provide reference for clinical pharmacists to perform pharmaceutical care work. Methods Original data of 100 hospitalized patients with AECOPD patients,treated in this hospital from Jan.to Mar.2016 were collected to evaluated the distribution of pathogens,drug frequency(DDDs),drug use index(DUI) and daily drug cost(DDC) of antibiotics. Results Among the 100 hospitalized patients,the usage rate of antibiotics was 99.00 %.The application of antibiotics involved 12 kinds of 7 categories.The highest constituent ratio was 37.37% of quinolone,followed by cephalosporins and β-lactamase inhibitor(27.37%).The treatment course of antibiotics was 1-33 days,with an average duration of (7.77±4.55) days.According to the DDDs ranking,the top 3 antibiotics were levofloxacin,cefodizime and cefoxitin,and according to DDC,the top 3 antibiotics were moxifloxacin,levofloxacin and azithromycin. Conclusion The mainly used antibiotics in this hospital were β-lactams and quinolones.The usage of antibiotics in this hospital could be basically reasonable,but there might still be some unreasonable usage in the treatment of AECOPD.

关 键 词：慢性阻塞性肺疾病急性加重期 抗菌药物 药物使用频度 药物利用指数 药物日治疗费用 

分 类 号：R563.9[医药卫生—呼吸系统]