冠状动脉病变与冠心病危险因素相关性分析  

Correlation analysis between coronary artery lesion and risk factors of coronary heart disease

作　　者：刘蕾 魏李江 殷兆芳[1] 韩志华[1] 孙婷[1] LIU Lei;WEI Li-jiang;YIN Zhao-fang;HAN Zhi-hua;SUN Ting(Department of Cardiology,Ninth Affiliated People's Hospital of Medical College,Shanghai Jiaotong University,Shanghai,200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院心内科

出　　处：《心血管康复医学杂志》2019年第5期561-566,共6页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：国家自然科学基金(81770505)~~

摘　　要：目的:探讨冠心病(CHD)患者冠状动脉病变严重程度与CHD危险因素之间的相关性。方法:回顾性分析2012年1月~2013年1月我院收治的452例行冠脉造影术且临床资料完整的病例,其中非CHD者64例(非CHD组),CHD患者388例(CHD组),探讨冠状动脉病变血管数目、长度、大小、狭窄程度与冠心病危险因素间的相关性。结果:(1)与非CHD组相比较,CHD组男性、高血压、糖尿病比例显著增加, P <0.05或<0.01;(2)CHD组中,与冠脉单支病变组比较,冠状动脉多支病变组患者年龄较大,高血压,糖尿病和低HDL-C血症患者比例显著增加( P <0.05或<0.01);与大血管病变患者比较,小血管病变患者年龄较大,合并糖尿病显著增加,吸烟比例显著降低( P 均<0.01);与狭窄<90%组比较,狭窄≥90%组患者LVEF水平显著降低,LDL-C水平升高患者比例显著增加( P <0.05或<0.01);(3)多重线性回归分析及直线相关分析表明:冠状动脉病变血管大小与患者年龄呈显著负相关( r =-0.181, P =0.001);冠脉病变严重程度与LVEF呈显著负相关( r =-0.213, P =0.001),与心率( r =0.133, P =0.009)、LDL-C水平( r =0.141, P =0.001)均呈显著正相关。结论:增龄、吸烟、合并糖尿病、高血压、高血脂、心率过快及左心室收缩功能减退等冠心病危险因素会进一步加重冠冠脉病变。Objective: To explore correlation between severity of coronary artery lesion and risk factors of coronary heart disease (CHD) in CHD patients. Methods: The 452 patients, who had clinical complete data and underwent coronary angiography in our hospital from Jan 2012 to Jan 2013 were retrospectively analyzed, including 64 non-CHD cases (non-CHD group) and 388 CHD cases (CHD group). Correlation among number, length, size, stenotic degree of diseased coronary artery vessels and CHD risk factors were explored. Results:(1) Compared with non-CHD group, there were significant rise in percentages of men, hypertension (EH) and diabetes mellitus (DM) in CHD group, P <0.05 or <0.01;(2)In CHD group, compared with single vessel coronary disease group, there were significant rise in age, percentages of EH, DM and patients with low HDL-C in multi-vessel coronary disease group, P <0.05 or <0.01;compared with large vessel lesion patients, there were significant rise in age and DM percentage, and significant reduction in percentage of smokers in small vessel lesion patients, P <0.01 all;compared with stenosis <90% group, there was significant reduction in LVEF and significant rise in percentage of patients with elevated LDL-C level in stenosis≥90% group, P <0.05 or <0.01;(3)Multivariate linear regression analysis and linear correlation analysis indicated that size of diseased coronary artery vessels was significant inversely correlated with age ( r =-0.181, P =0.001);severity of coronary disease was significant inversely correlated with LVEF ( r =-0.213, P =0.001), and significant positively correlated with heart rate ( r =0.133, P =0.009) and LDL-C level ( r =0.141, P =0.001). Conclusion: Risk factors for CHD,including aging,smoking,complicated DM,EH,hyperlipidemia,tachycardia and left ventricular systolic dysfunction etc.,will further aggravate coronary artery lesion.

关 键 词：冠心病 冠状血管 危险因素 

分 类 号：R541.409[医药卫生—心血管疾病]