单味中药鬼针草颗粒治疗高脂血症的疗效及其对血清MMP-9、TIMP-1水平的影响  

Therapeutic effect of single Chinese medicine Bidens pilosa grain on hyperlipidemia and its influence on serum levels of MMP-9 and TIMP-1

作　　者：邹振武 李德忠 彭绪东 王齐兵 张春龙 谭金波 何俊清 ZOU Zhen-wu;LI De-zhon;PENG Xu-dong;Wang Qi-bing;ZHANG Chun-long;TAN Jin-bo;HE Jun-qing(Department of Emergency,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi,Hubei,445000,China)

机构地区：[1]恩施土家族苗族自治州中心医院急诊中心

出　　处：《心血管康复医学杂志》2019年第5期661-665,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：2014年恩施州农业与社会发展科技指导性项目~~

摘　　要：目的:探讨单味中药鬼针草颗粒治疗高脂血症的疗效及其对血清基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制剂-1(TIMP-1)水平的影响。方法:2014年1月~2017年6月就诊于我院的高脂血症患者186例被随机分为鬼针草组(94例,在常规治疗基础上接受鬼针草)和血脂康组(92例,在常规治疗基础上接受血脂康),两组均治疗2个月。观察对比两组治疗前后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、MMP-9、TIMP-1水平及治疗总有效率。结果:与治疗前相比,治疗后两组血清TC、TG、LDL-C、MMP-9[鬼针草组(24.46±4.92)μg/L比(20.53±2.69)μg/L,血脂康组(23.40±2.57)μg/L比(19.98±2.02)μg/L]水平均显著降低,血清HDL-C[鬼针草组(1.28±0.45)mmol/L比(1.54±0.52)mmol/L,血脂康组(1.28±0.45)mmol/L比(1.55±0.52)mmol/L]、TIMP-1[鬼针草组(4.67±1.26)μg/L比(6.02±2.24)μg/L,血脂康组(4.63±1.30)μg/L比(6.01±2.31)μg/L]水平均显著升高,P均=0.001;治疗后,两组血清TC、TG、LDL-C、HDL-C、MMP-9、TIMP-1水平及总有效率均无显著差异,P均>0.05。结论:鬼针草能显著改善高脂血症患者血脂水平,降低血清MMP-9水平,提高血清TIMP-1水平,与血脂康无显著性差异。Objective: To explore therapeutic effect of single Chinese medicine Bidens pilosa grain on hyperlipidemia and its influence on serum levels of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinases-1(TIMP-1). Methods: A total of 186 hyperlipidemia patients treated in our hospital from Jan 2014 to Jun 2017 were randomly divided into Bidens pilosa group(n=94, received Bidens pilosa grain based on routine treatment) and Xuezhikang group(n=92, received Xuezhikang based on routine treatment). Both groups were treated for two months. Serum levels of total cholesterol(TC), triglyceride(TG), low density lipoprptein cholesterol(LDL- C), high density lipoprptein cholesterol(HDL-C), MMP-9 and TIMP-1 before and after treatment, and total effective rate were observed and compared between two groups. Results: Compared with before treatment, after treatment, there were significant reductions in serum levels of TC, TG, LDL-C and MMP-9[ Bidens pilosa group:(24.46±4.92)μg/L vs.(20.53±2.69)μg/L, Xuezhikang group:(23.40±2.57)μg/L vs.(19.98±2.02)μg/L], and significant rise in serum levels of HDL-C[ Bidens pilosa group:(1.28±0.45)mmol/L vs.(1.54±0.52)mmol/L,Xuezhikang group:(1.28±0.45)mmol/L vs.(1.55±0.52)mmol/L] and TIMP-1[ Bidens pilosa group:(4.67±1.26)μg/L vs.(6.02±2.24)μg/L, Xuezhikang group:(4.63±1.30)μg/L vs.(6.01±2.31)μg/L] in two groups, P =0.001 all. After treatment, there were no significant difference in serum levels of TC, TG, LDL-C, HDL-C, MMP-9 and TIMP-1 and total effective rate between two groups, P >0.05 all. Conclusion: Bidens pilosa can significantly improve serum lipid level, reduce serum level of MMP-9 and increase serum level of TIMP-1 in hyperlipidemia patients. It's no significant difference compared with Xuezhikang.

关 键 词：高脂血症 基质金属蛋白酶9 鬼针草属 

分 类 号：R589.2[医药卫生—内分泌]