儿童特应性皮炎严重度与维生素D水平的相关性  

The correlation between severity of atopic dermatitis and vitamin D level in children

作　　者：李梅云 谢丽 何欢[1] 程颖[1] 刘晓依[1] 张珍[1] 陈琢 陈戟[1] LI Meiyun;XIE Li;HE Huan;CHENG Ying;LIU Xiaoyi;ZHANG Zhen;CHEN Zhuo;CHEN Ji(Department of Dermatology,Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Clinical Research Center,Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属儿童医学中心皮肤科,上海200127 [2]上海交通大学医学院临床研究中心,上海200025

出　　处：《临床儿科杂志》2019年第10期727-730,共4页Journal of Clinical Pediatrics

基　　金：上海交通大学附属儿童医学中心院级课题(No.YJ-SCMC2017-12)

摘　　要：目的探讨儿童特应性皮炎(AD)疾病严重程度与维生素D水平的相关性。方法纳入152例AD患儿,以AD严重程度评分(SCORAD)评估AD严重度,液相色谱-串联质谱法检测血清25-羟维生素D[25(OH)D],分析AD严重程度与血清25(OH)D水平的相关性。结果152例AD患儿中,男81例、女71例,中位年龄3.5岁。轻度、中度、重度AD患儿分别为51例(33.6%)、80例(52.6%)、19例(12.5%)。血清25(OH)D充足55例(36.2%),不足65例(42.8%),缺乏32例(21.1%)。AD患儿SCORAD评分与血清25(OH)D水平无显著相关性(r=-0.047,P=0.567),与血清总IgE呈显著正相关(r=0.244,P=0.003),与血嗜酸性粒细胞比例呈显著正相关(r=0.239,P=0.004)。结论AD儿童中血清维生素D缺乏和不足者较多,但AD的严重程度与血清25(OH)D水平无显著相关性。Objective To study the correlation of serum vitamin D [25(OH)D] levels with the severity of childhood atopic dermatitis (AD). Methods A total of 152 children with AD were enrolled. The severity of AD was assessed by SCORAD. Serum 25(OH)D levels were determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). The correlation between the severity of AD and serum 25 (OH) D levels was analyzed. Results In the 152 children (81 males, 71 females) with AD, the median age was 3.5 years. There were 51 cases of mild AD (33.6%), 80 cases of moderate AD (52.6%), and 19 cases of severe AD (12.5%). Vitamin D was sufficient in 55 cases (36.2%), insufficient in 65 cases (42.8%), and deficient in 32 cases (21.1%). The SCORAD score in children with AD was not correlated with serum 25 (OH) D levels (r=.0.047, P=0.567), while positively correlated with total serum IgE (r=0.244, P=0.003) and the percentage of blood eosinophils (r=0.239, P=0.004). Conclusions Serum vitamin D insufficiency and deficiency were more common in AD children, but the severity of AD was not significantly correlated with serum 25 (OH) D levels.

关 键 词：特应性皮炎 维生素D 总IGE 疾病严重程度指数 儿童 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]