巨噬细胞对腹膜透析相关性腹膜纤维化研究进展  

Research advances in the function of macrophages in peritoneal dialysis related peritoneal fibrosis

作　　者：唐寒芬 朱旭萍[2] 刘伏友[1] TANG Han-fen;ZHU Xu-ping;LIU Fu-you(Department of Nephrology,Xiangya second Hospital,Central South University,Changsha 410011;Department of Nutrition,The Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院肾内科,长沙410011 [2]中南大学湘雅二医院营养科,长沙410011

出　　处：《中国血液净化》2019年第9期597-599,共3页Chinese Journal of Blood Purification

基　　金：湖南省自然科学基金课题,课题编号为2019JJ50862

摘　　要：腹膜透析是终末期肾病患者的三大替代治疗方法之一。腹膜透析相关性腹膜纤维化是腹膜透析的主要并发症,也是腹膜透析治疗失败的重要原因之一。腹膜透析相关性腹膜纤维化主要发病机制有转化生长因子-β1表达异常、微小RNA表达异常以及上皮间质转化等。近年来,研究发现巨噬细胞在腹膜纤维化的发生和发展中发挥着重要的作用。本文主要就巨噬细胞对腹膜透析相关性腹膜纤维化的研究进展进行综述。Peritoneal dialysis (PD) is one of the three effective treatments for end- stage renal failure. However, peritoneal fibrosis is an important complication in PD patients, and is one of the important causes leading to failure of PD. The pathogenesis of peritoneal fibrosis includes abnormal expressions of transforming growth factor-β1 and microRNA, epithelial- mesenchymal transition, etc. Recently, many studies report that macrophages play an important part in the occurrence and development of peritoneal fibrosis. This review focuses on the research advances in macrophage cells in the pathogenesis of PD related peritoneal fibrosis.

关 键 词：腹膜纤维化 巨噬细胞 转化生长因子-Β1 上皮-间充质转化 微小RNA 

分 类 号：R459.5[医药卫生—治疗学]