3种黄芪属植物提取物对血小板聚集的影响  

Influence of the Extracts from Three Astragalus Plants on Platelet Aggregation

作　　者：沈磊 崔淑君 王敏 姜北 Shen Lei;Cui Shujun;Wang Min;Jiang Bei(Institute of Materia Medica,Dali University,Dali,Yunnan 671000,China;College of Pharmacy and Chemistry,Dali University,Dali,Yunnan 671000,China)

机构地区：[1]大理大学药物研究所,云南大理671000 [2]大理大学药学与化学学院,云南大理671000

出　　处：《大理大学学报》2019年第10期22-26,共5页Journal of Dali University

基　　金：国家自然科学基金资助项目（31170313）;大理大学博士启动费资助项目（KYBS201411）;大理大学滇西特色药用植物与白族药开发利用创新团队项目（ZKLX2019106）

摘　　要：目的:研究3种黄芪属黄芪亚属植物(正品黄芪、梭果黄芪和云南黄芪)提取物对血小板聚集的影响。方法:制备含血小板血浆,加不同浓度的3种黄芪属植物提取物孵育后,再加入二磷酸腺苷(ADP)和花生四烯酸(AA)诱导血小板聚集或者不加诱导剂,观察药物对血小板聚集的影响。结果:正品黄芪、梭果黄芪和云南黄芪的提取物均能明显抑制ADP和AA诱导的血小板聚集,其中正品黄芪与梭果黄芪对ADP诱导血小板聚集的抑制作用强于云南黄芪,而云南黄芪与梭果黄芪对AA诱导血小板聚集的抑制作用强于正品黄芪;3种黄芪属植物的提取物均有一定的促进正常血小板聚集的作用。结论:3种黄芪属植物提取物均能抑制不同诱导剂促进血小板聚集的作用,但具体作用途径有差异。Objective: To study the influence of the alcoholic extracts from three Astragalus plants(A. membranaceus, A. ernestii, and A. yunnanensis)on platelet aggregation. Methods: After preparation of platelet-containing plasma, different concentrations of the extracts of the three Astragalus plants were added to incubate plasma, then their effects on adenosine diphosphate (ADP) or arachidonic acid(AA)-induced platelet aggregation, or on the situation without inducer, were observed. Results: Compared with solvent control group, all the extracts from the three Astragalus plants significantly inhibited ADP or AA-induced platelet aggregation;the inhibitory effects of the extracts from A. membranaceus and A. ernestii on ADP-induced aggregation are better than the extract from A. yunnanensis, while the effects of the extracts from A. yunnanensis and A. ernestii on AA-induced aggregation are better than the extract from A. membranaceus. The extracts from the three Astragalus plants also could promote normal platelet aggregation. Conclusion: All the extracts from three Astragalus plants can inhibit platelet aggregation by different inducer, but their inhibitory mechanisms are different.

关 键 词：黄芪属植物 血小板聚集 二磷酸腺苷 花生四烯酸 

分 类 号：R285.5[医药卫生—中药学]