快速降解的弹性体(PGS/PCL)人工血管重建肌性功能性颈动脉的实验研究  

Biodegrading elastomeric PGS/PCL artificial vessel regenerates muscular and functional carotid artery

作　　者：杨欣 杨帆[2] 郭晓宝 吴炜 高瞻[1] YANG Xin;YANG Fan;GUO Xiaobao;WU Wei;GAO Zhan(Urumchi, Department of Oral and Maxillofacial Surgery, General Hospital of Xinjiang Military Region,830000 China;Regiment Medical Company, The People's Liberation Army 69330 Troop, Barkol;State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University)

机构地区：[1]新疆军区总医院颌面外科,乌鲁木齐830000 [2]中国人民解放军69330部队卫生队 [3]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院颌面外科

出　　处：《实用口腔医学杂志》2019年第5期647-652,共6页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:31370997);国家高技术研究发展计划(编号:863计划,2015AA020920)

摘　　要：目的:研究快速降解的弹性体PGS/PCL人工血管在体内改建为功能性肌性颈动脉的可能性。方法:体外构建PGS/PCL双层人工血管,植入大鼠颈动脉,12个月后取材,对新生血管进行评估。结果:12个月后,PGS/PCL人工血管改建成了与自体颈动脉结构和组织学方面均相似的细胞化的新生血管。结论:PGS/PCL人工血管在体内可以改建成为肌性、功能性的动脉血管。Objective: To investigate the feasibility of fast degrading and elastomeric PGS/PCL artificial vessel in the reconstruction of carotid artery. Methods:PGS/PCL artificial vessel was fabricated in vitro. Artificial vessels were interpositioned in rat carotid arteries, the results were evaluated at 1 year postoperatively. Results: PGS/PCL artificial vessel remodeled into cellular "neoarteries" approxi mate to native carotid arteries. Conclusion: PGS/PCL artificial vessel can be remodeled into muscular and functional artery in vivo.

关 键 词：颈动脉重建 颈动脉置换 聚癸二酸丙三酮酯(PGS) 

分 类 号：R318.08[医药卫生—生物医学工程] R782[医药卫生—基础医学]