磁性氧化铁纳米粒在肿瘤诊疗一体化中的应用  

Application of iron oxide magnetic nanoparticles in tumor theranostics

作　　者：龚斯曼 蓝思逸 李菁[1] 孙敏捷[1] GONG Siman;LAN Siyi;LI Jing;SUN Minjie(Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学药剂学教研室

出　　处：《中国药科大学学报》2019年第5期531-539,共9页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81573377)~~

摘　　要：随着纳米技术在肿瘤学领域的高速发展,肿瘤治疗正迅速转向为更加精准的个性化治疗,具备肿瘤诊断和治疗能力的诊疗一体化制剂由此成为新的研究热点。磁性氧化铁纳米粒(IONP)由于其独特的成像性能、稳定的产热性能、较好的生物相容性及表面易于修饰的特点而广泛应用于诊疗一体化体系中。本文分析了IONP用于肿瘤诊断和治疗的优势,并详细介绍了近年来的新兴策略和研究进展,包括磁共振成像技术、光热疗技术、磁热疗技术和磁靶向技术等。最后,对IONP在临床肿瘤诊疗一体化中的应用提出了设想与展望。With the rapid development of nanotechnology,accurate personalized treatments for tumor have attracted more attention to increase the therapeutic effects and reduce the side effects.The emerging theranostic systems incorporating different therapeutic and diagnostic imaging capabilities have become a new research hotspot.Magnetic iron oxide nanoparticles(IONP) have been widely used in theranostic systems due to their unique imaging properties,stable thermal performance,excellent biocompatibility and admirable surface modifiability.In this review,we analyzed the advantages of IONP in the diagnosis and the treatment of tumor,and detailedly introduced the relevant strategies and latest research progress,including magnetic resonance imaging(MRI),photothermal therapy,magnetic hyperthermia,and magnetic targeted drug delivery,etc.Finally,the potential application of IONP in the clinical tumor theranostics was proposed.

关 键 词：氧化铁 磁性纳米粒 诊疗一体化 磁共振成像 肿瘤治疗 

分 类 号：R944[医药卫生—药剂学]