血小板分析仪、血小板聚集仪和血栓弹力图仪检测血小板聚集率  

Correlation Analysis of Platelet Aggregation Rate Detected by Platelet Analyzer,Platelet Aggregometer and Thromboelastography

作　　者：江慧[1] 苏蕊[2] 洪强[1] JIANG Hui;SU Rui;HONG Qiang(Department of Blood Transfusion,The First Affiliated Hospital of Xiamen University,Xiamen 361000Fujian Province,China;Department of Hematology,The First Affiliated Hospital of Xiamen University,Xiamen 361000Fujian Province,China)

机构地区：[1]厦门大学附属第一医院输血科,福建厦门361000 [2]厦门大学附属第一医院血液科,福建厦门361000

出　　处：《中国实验血液学杂志》2019年第5期1622-1626,共5页Journal of Experimental Hematology

摘　　要：目的:分析并比较血小板分析仪、血小板聚集仪和血栓弹力图仪三者检测血小板聚集率的相关性。方法:对血小板分析仪在血小板计数和血小板聚集功能的性能方面进行评估;分别采用血栓弹力图仪、血小板聚集仪和血小板分析仪对55例2型糖尿病(T2DM)患者,单用阿司匹林(32例)、单用氯匹格雷(23例)前后血小板聚集率进行测定,并对检测结果进行比较,进一步分析不同仪器设备所测结果的相关性,将所得数据纳入统计学分析。结果:血小板分析仪日间和批内精密度均低于1/3总误差(7%),携带污染率为0.30%,在4.15×10^9/L至1379.95×10^9/L的线性范围内的回归方程斜率为1.02,R^2=0.99,血小板计数所测结果与血小板参考方法的检测结果符合率达85%,符合行业标准要求。血栓弹力图仪、血小板聚集仪和血小板分析仪测定T2DM患者单用氯匹格雷和阿司匹林后血小板聚集率较服药前明显下降(P<0.01)。结论:血小板分析仪能够为临床检测血小板计数和聚集功能提供可靠、客观、准确的信息,并符合行业标准要求,且其与血小板聚集仪和血栓弹力图仪对血小板聚集率的检测结果相当。Objective:To analyze and compare the correlation of platelet aggregation rate measured by platelet analyzer,platelet aggregometer and thromboelastography.Methods:The performance of platelet analyzer in platelet count and platelet aggregation function was evaluated.The platelet aggregation rate of 55 patients with type 2 diabetes mellitus(T2DM)before and after taking aspirin alone(32 cases)and clopidogrel alone(23 cases)was measured by thromboelastography,platelet aggregometer and platelet analyzer respectively,and the analytical results were compared.The correlation between the results measured by different instruments and equipment were further analyzed and the data were included in the statistical analysis.Results:The precision of platelet analyzer in day and in batch was 1/3 lower than the total error(7%).The contamination rate was 0.30%.The slope of regression equation was 1.02 and R^2 was 0.99 in the linear range of 4.15×10^9/L to 1379.95×10^9/L.The coincidence rate of platelet count and platelet reference method was 85%,which met the requirements of industry standards.The platelet aggregation rates of patients with T2DM after clopidogrel or aspirin by using thromboelastography,platelet aggregometer and platelet analyzer respectively was significantly lower than those whom before clopidogrel administration(P<0.01).Conclusion:Platelet analyzer can provide reliable,objective and accurate information for clinical detection of platelet count and aggregation function,which is meet the requirements of industry standards,and its results are similar to those of platelet aggregometer and thromboelastography.

关 键 词：血小板聚集率 血栓弹力图仪 血小板聚集仪 血小板分析仪 

分 类 号：R446.11[医药卫生—诊断学] R331[医药卫生—临床医学]