原发性免疫性血小板减少症的发病机制研究进展  

Research Advances on the Pathogenesis of Primary Immune Thrombocytopenia——Review

作　　者：袁永平 杨翔 陈懿建[2] YUAN Yong-Ping;YANG Xiang;CHEN Yi-Jian(Gannan Medical College;Department of Hematology,The First Affiliated Hospital of Gannan Medical College,Ganzhou 341000,Jiangxi Province,China)

机构地区：[1]赣南医学院 [2]赣南医学院第一附属医院血液科,江西赣州341000

出　　处：《中国实验血液学杂志》2019年第5期1706-1710,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金(81060047,81160073);江西省自然科学基金(20132BAB205053);江西省卫生厅重大项目基金(20114011);江西省教育厅科技落地计划(KJLD14085)

摘　　要：原发性免疫性血小板减少症(Immune thrombocytopenia,ITP)是一种复杂的自身免疫疾病,以外周血中血小板计数<100×10^9/L为特点。ITP的发病机制复杂,尚未完全阐明,目前对ITP发病的研究主要针对于体液免疫失调以及细胞免疫失调等方面。近年来,研究该发病机制取得了一些新的进展,包括非依赖FcγR介导的血小板清除途径,可以调节T、B细胞的金属蛋白酶(ADAM)10,遗传因素中的微小RNA的表达异常等。在多种因素的共同作用下,机体免疫系统的失衡,导致ITP的发生。本文就近年来针对ITP研究的体液免疫,细胞免疫以及其他可能的新发病机制研究进展进行综述。Immune thrombocytopenia(ITP)is a complex autoimmune disease characterized by less than 100×10^9/L platelet count in peripheral blood.The pathogenesis of ITP is complex and has not been fully elucidated.Currently,researches on the pathogenesis of ITP mainly focus on the disorders of humoral immunity and cellular immunity.In recent years,some new progress has been made in the study of this pathogenesis,including the platelet clearance pathway that is not dependent on FcγR mediation,the metalloproteinase(ADAM)10 that can regulate T and B cells,and the abnormal expression of micro RNA in genetic factors.Under the joint action of multiple factors,the imbalance of the immune system in the body leads to the occurrence of ITP.This article reviews the research progress on humoral immunity,cellular immunity and other possible new pathogenesis of ITP in recent years.

关 键 词：免疫性血小板减少性紫癜 自身抗体 CD4+T细胞 AMR受体 

分 类 号：R558.2[医药卫生—血液循环系统疾病]