反复上呼吸道感染患儿补充维生素D后LL-37、IL-10含量变化  

Changes of LL-37 and IL-10 levels in children with recurrentupper respiratory tract infection after vitamin D supplementation

作　　者：王博玉[1] 杨小巍[1] 谢雪兰[1] 石瑄[1] 安晓肖[1] WANG Boyu;YANG Xiaowei;XIE Xuelan;SHI Xuan;AN Xiaoxiao(Affiliated Hospital of Hebei University,Baoding 071000,China)

机构地区：[1]河北大学附属医院

出　　处：《医学研究与教育》2019年第5期1-6,共6页Medical Research and Education

基　　金：河北省卫生计生委医学科学研究课题计划项目(HB2017ADE007)

摘　　要：目的研究反复上呼吸道感染与LL-37、IL-10及维生素D的相关性。方法将64例反复呼吸道感染患儿随机分成2组,实验组给予常规治疗同时补充维生素D,对照组给予常规治疗同时给予安慰剂。随访12个月,检测治疗前基线含量和治疗12个月后血浆25-羟维生素D3、IL-10及痰上清LL-37的变化。结果实验组与对照组比较,LL-37、IL-10及25-羟维生素D3含量均显著增高(P<0.05),呼吸道感染次数显著下降(P<0.05)。实验组治疗12个月后25-羟维生素D3、LL-37、IL-10均显著增高(P<0.05),呼吸道感染次数显著下降(P<0.05)。实验组治疗12个月后LL-37含量、IL-10含量、25-羟维生素D3含量均呈正相关(P<0.05)。讨论补充维生素D有助于减少反复上呼吸道感染次数,这种作用可能与LL-37及IL-10产生增加有关。Objective To study the correlation between recurrent upper respiratory tract infection and LL-37,IL-10 and vitamin D. Methods 64 children with recurrent respiratory infection were randomly divided into two groups.The experimental group was treated in a routine way with vitamin D supplementation,while the control group was treated in a routine way with placebo.The follow-up period was 12 months.Plasma 25-hydeoxyvitamin D 3,IL-10 and sputum supernatant LL-37 at baseline before treatment and changes of them after 12 months were detected. Results Compared with the control group,the content of LL-37,IL-10 and 25-hydroxyvitamin D 3 in the experimental group were significantly increased (P<0.05),while the number of respiratory infections was decreased significantly (P<0.05).In the experimental group,the content of LL-37,IL-10 and 25-hydroxyvitamin D 3 were significantly increased after 12 months treatment (P<0.05),while the number of upper respiratory infections was decreased significantly (P<0.05).The LL-37 content,IL-10 content and 25-hydroxyvitamin D 3 content in the experimental group were positively correlated (P<0.05). Discussion Vitamin D supplementation.

关 键 词：反复呼吸道感染 维生素D3 LL-37 白介素10 

分 类 号：R56[医药卫生—呼吸系统]