小分子化合物在诱导干细胞分化为胰岛素分泌细胞中的研究进展  

Advance of small molecule compounds in inducing stem cells to differentiate into insulin-producing cells

作　　者：黄艳婷 刘建萍[1] HUANG Yan-Ting;LIU Jian-Ping(The Second Afiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院

出　　处：《生命科学》2019年第8期842-848,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81760150,81560554);江西省自然科学基金项目(20151BAB205019)

摘　　要：干细胞具有多向分化潜能,可以被小分子化合物诱导分化为胰岛素分泌细胞,进而移植到体内代替受损的胰岛β细胞,从根本上治愈糖尿病。小分子化合物种类繁多,具有无免疫原性、可控性强等优点,因此,利用小分子化合物诱导干细胞分化为胰岛素分泌细胞来治疗糖尿病是将来比较有前景的治疗方案。该综述主要分类概述了化学诱导法中经常使用的小分子化合物及其在相应阶段发挥的作用。Stem cells are a class of cells with the potential of multidirectional differentiation,which can be induced by small molecules to differentiate into insulin-producing cells and then transplanted into the body to replace the damagedβcells,so as to fundamentally cure diabetes.There are many kinds of small molecule compounds with the advantages of non-immunogenicity and strong controllability.Therefore,it is a promising treatment of using small molecule compounds to induce stem cells to differentiate into insulin-producing cells in the future.In this review,we summarizes the small molecules frequently used in the chemical induction method and their roles in the corresponding stages.

关 键 词：糖尿病 干细胞 胰岛素分泌细胞 小分子化合物 

分 类 号：R587.1[医药卫生—内分泌]