磁场响应的纳米材料与磁热效应生物医学应用  

Magnetic field-responsive nanomaterials and biomedical application of magnetic hyperthermia

作　　者：高飞 张廷斌 张欢 张艺凡 刘晓丽[2] 樊海明 GAO Fei;ZHANG Tingbin;ZHANG Huan;ZHANG Yifan;LIU Xiaoli;FAN Haiming(Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education,College of Chemistry and Materials Science,Northwest University,Xi'an 710127,China;College of Life Sciences,Northwest University,Xi'an 710069,China)

机构地区：[1]西北大学化学与材料科学学院,教育部合成与天然功能分子化学重点实验室,西安710127 [2]西北大学生命科学与医学部,西安710069

出　　处：《生命的化学》2019年第5期903-916,共14页Chemistry of Life

基　　金：国家自然科学基金项目(81771981,81571809)

摘　　要：以氧化铁为代表的磁场响应型纳米材料具有良好的生物相容性、独特的磁学性能、可调控的体内代谢行为,而且易于表面修饰。上述特性使磁场响应型纳米材料及磁调控的生物学效应在分子检测、疾病诊断和治疗等诸多生物医学领域展示出巨大的应用潜力。本文介绍了近几年出现的新型磁场响应型纳米材料以及其磁热效应,比较了宏观磁热与纳米磁热效应,并对磁热效应在肿瘤治疗及其他生物医学应用进行了阐述。Due to their unique magnetic properties,well biocompatibility,facile surface modification, and controllable metabolic behavior,the magnetic field-responsive nanomaterials have been considered as promising materials in molecular detection,disease diagnosis and treatment for biomedical applications.In this review,we focused on the recent progress in novel magnetic field-responsive nanomaterials and their hyperthermia effect.Both macroscopic heating effects and localized nanothermal effects were discussed in detail.The applications of these biological effects in cancer treatment and other biomedical fields were also presented.

关 键 词：磁场 磁性纳米材料 磁热 生物学效应 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318[医药卫生—生物医学工程]