岩藻聚糖硫酸酯的抗肿瘤机制  

Research progress of fucoidan in anti-tumor mechanism

作　　者：白旭 胡波 宋淑亮 梁浩 吉爱国 BAI Xu;HU Bo;SONG Shuliang;LIANG Hao;JI Aiguo(Marine College,Shandong University,Weihai 264209,China;School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学(威海)海洋学院,威海264209 [2]山东大学药学院,济南250012

出　　处：《生命的化学》2019年第5期998-1003,共6页Chemistry of Life

基　　金：国家自然科学基金项目(81371455)

摘　　要：岩藻聚糖硫酸酯是褐藻所固有的细胞间多糖,也是其特有的活性物质,具有多种生物学功能,包括抗癌、抗凝血、降血脂等。目前岩藻聚糖硫酸酯抗肿瘤活性虽然已被大家熟知,但是抗肿瘤的具体机制仍不明确。因此,本文就岩藻聚糖硫酸酯在诱导肿瘤细胞凋亡、阻滞肿瘤细胞周期、抑制肿瘤细胞侵袭与转移、抑制肿瘤细胞血管生成方面的机制的研究进展进行了综述,以期为将岩藻聚糖硫酸酯开发为抗肿瘤药物提供研究思路。Fucoidan is a peculiar intercellular polysaccharide in brown algae,which is a unique active substance with various biological functions,including anti-cancer,anti-coagulation and hypolipidemic.Although the antitumor activity of fucoidan has been well known,the specific mechanism of antitumor is still unclear. This paper reviews the research progress of fucoidan in inducing tumor cell apoptosis,blocking tumor cell cycle, inhibiting tumor cell invasion and metastasis,and inhibiting tumor cell angiogenesis,which could provide research ideas for the development of fucoidan as an anti-tumor drug.

关 键 词：岩藻聚糖硫酸酯 抗肿瘤 凋亡 细胞周期 侵袭与转移 血管生成 

分 类 号：R96[医药卫生—药理学]