干扰素诱导蛋白GBP2的生物学功能  

The biological function of guanylate binding protein 2

作　　者：唐近洪 杨海涛 王泽方 TANG Jinhong;YANG Haitao;WANG Zefang(College of Life Science,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津大学生命科学学院

出　　处：《生命的化学》2019年第5期1019-1024,共6页Chemistry of Life

基　　金：国家重点基础研究发展计划(“973”计划)(2014CB542800,2015CB859800);国家重点研发计划(2016YFD0500300);国家自然科学基金项目(31528006)

摘　　要：鸟苷酸结合蛋白2(guanylate binding protein 2,GBP2)是一种干扰素(interferon,IFN)诱导蛋白,同时是鸟苷酸结合蛋白家族(GBPs)的成员之一。GBP2能够在宿主抵抗原生动物、病毒和细菌感染方面发挥生物学功能。在抗肿瘤方面,GBP2可能作为肿瘤发展过程的控调节因子以及肿瘤标志物。该综述围绕人类GBP2和小鼠Gbp2关于抗感染及抗肿瘤方面的最新生物学功能展开讨论,以期为GBP2在抗原生动物、病毒、细菌感染及抗肿瘤治疗领域的进一步研究提供理论依据。Guanylate binding protein 2 (GBP2) is an interferon (IFN)-induced protein.GBP2 is one of the members of GBP family.Current research show that GBP2 resists infection in the field of host against protozoa,viruses and bacteria.In the field of anti-tumor,GBP2 could be used as a controllable regulator during tumor development and tumor marker.This review will summary recent research progresses of human GBP2 and mouse Gbp2 on anti-infection and anti-tumor to provide some basic theoretical references about the treatment research of infection and tumor.

关 键 词：GBP2 抗感染 抗肿瘤 

分 类 号：R341[医药卫生—基础医学]