海洋来源硫酸软骨素降解酶的研究进展  

Research progress in chondroitinase from marine bacteria

作　　者：王文爽[1] 许莹莹 石立冉 李福川[1] WANG Wen-Shuang;XU Ying-Ying;SHI Li-Ran;LI Fu-Chuan(National Glycoengineering Research Center,Shandong University,Qingdao 266237,China)

机构地区：[1]山东大学国家糖工程技术研究中心

出　　处：《生命科学》2019年第9期894-901,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31570071,31800665);山东省自然科学基金项目(ZR2018BC013)

摘　　要：硫酸软骨素作为糖胺聚糖的一类,广泛分布于细胞膜表面及细胞基质中,参与了一系列生理和病理过程。硫酸软骨素的功能多样性与其结构多样性密切相关,而硫酸软骨素降解酶在硫酸软骨素/硫酸皮肤素构效关系研究中发挥了重要作用。该文结合笔者工作,全面阐述了目前商品化硫酸软骨素降解酶的种类、作用机制,以及近期在海洋细菌中发现和鉴定的硫酸软骨素降解酶。最后,对海洋来源硫酸软骨素降解酶进行了展望。As a class of glycosaminoglycans,chondroitin sulfate is widely distributed on the cell membrane surface and in the cell matrix,and participates in a series of physiological and pathological processes.The functional diversity of chondroitin sulfate is closely related to its structural diversity,and chondroitin sulfate-degrading enzymes play a huge role in the study of chondroitin sulfate/dermatan sulfate structure-activity relationship.This paper comprehensively illuminates the types and mechanisms of commercial chondroitin sulfate-degrading enzymes and the chondroitin sulfate-degrading enzymes recently discovered and identified in the marine bacteria.Finally,the marine source enzymes are prospected.

关 键 词：硫酸软骨素 海洋细菌 水解酶 裂解酶 

分 类 号：Q55[生物学—生物化学]