血清性激素PRL FSH LHT和E2对非嵌合型克氏综合征的筛查价值  

Screening Value of Serum Sex Hormones PRL FSH LH T and E2 for Non-chimeric Klinefelter Syndrome

作　　者：李敏[1] 童芳芳[1] LI Min;TONG Fangfang(Qianjiang Central Hospital of Hubei,Hubei Qianjiang 433199,China)

机构地区：[1]湖北省潜江市中心医院检验科

出　　处：《河北医学》2019年第10期1631-1634,共4页Hebei Medicine

基　　金：湖北省卫生和计划生育委员会医药院校科研项目,(编号:WJ2016-YZ-16)

摘　　要：目的:分析血清性激素垂体泌乳素(PRL)、促卵泡激素(FSH)、黄体生成素(LH)、睾酮(T)和雌二醇(E2)对非嵌合型克氏综合征的筛查价值。方法:选择我院2013年1月至2018年1月收治的140例非嵌型克氏综合征患者,随机选择98例同期染色体核型正常的男性不育症患者为对照组。比较两组血清性激素PRL、FSH、LH、T和E2水平,分析受试者工作绘制特征(ROC)曲线对各指标的筛查价值。结果:非嵌合型克氏综合征组PRL、FSH、LH及E2水平均高于对照组(11.34±1.90)vs(8.01±1.14)ng/mL,(25.71±4.30)vs(9.60±1.57)mIU/mL,(23.18±3.21)vs(5.79±0.85)mIU/mL,(22.09±3.86)vs(18.43±2.40)pg/mL,T水平低于对照组(165.43±23.18)vs(428.10±67.41)ng/dl(P均<0.05)。ROC曲线显示,PRL及FSH、LH、T和E2曲线下面积分别为0.725、0.690、0.656、0.774、0.663,联合测定曲线下面积为0.890,联合测定曲线下面积明显高于单个指标(P<0.05)。结论:血清性激素PRL、FSH、LH、T和E2水平对非嵌合型克氏综合征有一定诊断价值,可作为此类疾病的初步筛查指标,为临床诊断提供依据。Objective: To analyze the screening value of serum sex hormones pituitrin (PRL),follicle-stimulating hormone (FSH),luteinizing hormone (LH),testosterone (T) and estradiol (E2) for non-chimeric klinefelter syndrome. Methods: 140 cases of non-chinmeric klinefelter syndrome patients who treated from January 2013 to January 2018 in our hospital,and 98 cases of male infertility with normal chromosome karyotype at the same time were randomly selected as the control group. The levels of serum sex hormones PRL,FSH,LH,T and E2 in both groups were compared,and analyze the screening value of the ROC curve for each indicator. Results: Levels of PRL,FSH,LH and E2 in non-chimeric klinefelter syndrome group were higher in the than the control group (11.34±1.90)vs(8.01±1.14)ng/mL,(25.71±4.30)vs(9.60±1.57)mIU/mL,(23.18±3.21)vs(5.79±0.85)mIU/mL,(22.09±3.86)vs(18.43±2.40)pg/mL,and levels of T in non-chimeric patients group was lower than those in the control group (all P<0.05). The ROC curve shows that the area under the curve of PRL and FSH,LH,T and E2 was 0.725,0.690,0.656,0.774 and 0.663,the area under the combined measurement curve was significantly higher than that of a single index (P<0.05). Conclusion: serum sex hormone PRL,FSH,LH,T and E2 levels have certain diagnostic value for non-chimeric klinefelter syndrome and can be used as a preliminary screening index for such diseases,providing a basis for clinical diagnosis.

关 键 词：非嵌合型克氏综合征 性激素 筛查价值 

分 类 号：R596[医药卫生—内科学] R446.6[医药卫生—临床医学]