apoA1/apoB Lp(a)在高胆固醇血症患者中的变化及意义  

Changes and Significance of apoA1/apoB and Lp(a) in Patients with Hypercholesterolemia

作　　者：陈莹 张博 CHEN Ying;ZHANG Bo(Nantong Hospital of Traditional Chinese Medicine,Jiangsu Nantong 226000,China)

机构地区：[1]江苏省南通市中医院检验科

出　　处：《河北医学》2019年第10期1744-1747,共4页Hebei Medicine

基　　金：江苏省卫生厅面上科研课题项目,(编号:H201106)

摘　　要：目的:探讨载脂蛋白A1(apoA1)/apoB、脂蛋白(α)Lp(a)在高胆固醇血症患者中的变化及意义。方法:选择2017年1月至2017年11月我院接诊的150例高胆固醇血症患者作为观察组,并选择我院同期接受健康体检的150例健康者作为对照组,采集所有人员入组后第2天清晨空腹静脉血,检测低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、apoA1、apoB、apoA1/apoB、Lp(a)的表达,分析apoA1/apoB、Lp(a)在高胆固醇血症患者中的变化及意义。结果:观察组LDL-C、TC、HDL-C、apoA1、apoB、apoA1/apoB、Lp(a)分别为(5.71±0.36)mmoL/L、(6.83±0.47)mmoL/L、(1.04±0.07)mmoL/L、(1.07±0.18)g/L、(1.07±0.23)g/L、(1.06±0.32)、(258.18±20.95)mg/L,对照组分别为(1.78±0.12)mmoL/L、(3.62±0.29)mmoL/L、(1.34±0.07)mmoL/L、(0.38±0.22)g/L、(0.84±0.08)g/L、(1.67±0.32)、(154.82±17.49)mg/L,差异具有统计学意义(P<0.05);通过Pearson相关性分析显示,apoA1/apoB和LDL-C、TC均呈负相关(r=-0.682、-0.679,P<0.05),Lp(a)和LDL-C、TC均呈正相关(r=0.926,0.909,P<0.05)。结论:高胆固醇血症患者存在着明显的脂质代谢紊乱,而apoA1/apoB降低、Lp(a)升高可良好的反映患者脂质代谢紊乱情况,本研究也为临床治疗高胆固醇血症提供了新思路。Objective: To study the changes and significance of apolipoprotein(apo)A1/apoB and lipoprotein(Lp)(a) in patients with hypercholesterolemia. Methods: 150 patients with hypercholesterolemia received from January 2017 to November 2017 were selected as the observation group,and 150 healthy were selected in our hospital for the same period as the control group. All personnel were collected from fasting venous blood at 2d after admission,the expression of low density lipoprotein cholesterol (LDL-C),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),triglyceride (TG),apoA1,apoB,apoA1/apoB,Lp(a) were detected,to analyze the changes and significance of apoA1/apoB and Lp(a) in patients with hypercholesterolemia. Results: The LDL-C,TC,HDL-C,apoA1,apoB,apoA1/apoB and Lp(a) in the observation group were(5.71±0.36)mmol/L,(6.83±0.47)mmol/L,(1.04±0.07)mmol/L,(1.07±0.18)g/L,(1.07±0.23)g/L、(1.06±0.32),(258.18±20.95)mg/L respectively,in the control group were(1.78±0.12)mmol/L,(3.62±0.29)mmol/L,(1.34±0.07)mmol/L,(0.38±0.22)g/L,(0.84±0.08)g/L,(1.67±0.32),(154.82±17.49)mg/L respectively,the differences has statistically significant(P<0.05);the Pearson correlation analysis showed that there was negatively correlated between apoA1/apoB and LDL-C and TC(r=-0.682,-0.679,P<0.05),there was a positive correlation between Lp(a) and LDL-C and TC(r=0.926,0.909,P<0.05). Conclusion: There is obvious disorder of lipid metabolism in patients with hypercholesterolemia,and the decrease of apoA1/apoB and the increase of Lp (a) can reflect the disorder of lipid metabolism,this study also provides a new way for clinical treatment of hypercholesterolemia.

关 键 词：高胆固醇血症 低密度脂蛋白胆固醇 总胆固醇 载脂蛋白 脂蛋白 

分 类 号：R589.2[医药卫生—内分泌]