单侧或双侧隐睾下降固定术对IVF/ICSI-ET助孕治疗结局的影响  

The Effect of Unilateral/Bilateral Orchidopexy on the Outcome of IVF/ICSI-ET Assisted Pregnancy Treatment

作　　者：刘珊 史霖[2] 王婷 LIU Shan;SHI Lin;WANG Ting(Assisted Reproduction Center,Northwest Women's and Children'sHospital,Xi'an 710003,Shaanxi,China;Department ofPathogenic Biology and Immunology,School of Basic Medicine of Xi'anJiaotong University,Xi'an 710061,Shaannxi,China)

机构地区：[1]西北妇女儿童医院辅助生殖中心,陕西西安710003 [2]西安交通大学基础医学院病原生物学与免疫学系,陕西西安710061

出　　处：《贵州医科大学学报》2019年第10期1215-1218,共4页Journal of Guizhou Medical University

基　　金：陕西省重点研发计划项目(2017SF-121)

摘　　要：目的:探讨行体外受精/卵泡浆内单精子注射授精-胚胎移植(IVF/ICSI-ET)助孕治疗的不孕患者中,男方曾经单侧或双侧隐睾下降固定术对辅助生殖治疗结局的影响。方法:将IVF/ICSI-ET治疗的隐睾下降固定手术史患者分为单侧隐睾下降固定术组52例、双侧隐睾下降固定术组39例,比较2组男女双方年龄、不孕时间等一般情况、男方精液、受精情况、促排情况及妊娠结局。结果:双侧隐睾下降固定手术组患者精液浓度和精液活率均显著低于单侧组(均P<0.001),IVF受精率及IVF正常受精率也显著低于单侧组(均P<0.001),但2组ICSI受精率及正常受精率比较差异无统计学意义(P>0.05);2组患者所获优胚数、临床妊娠率和活产率比较差异无统计学意义(P>0.05)。结论:双侧隐睾下降固定术患者的精液质量和受精能力受到较大影响,但通过ICSI辅助受精,可以显著提高助孕成功率。Objective:To explore the effect of unilateral or bilateral orchidopexy on the outcome of assisted reproductive therapy in infertile patients undergoing IVF/ICSI-ET assisted pregnancy treatment.Methods:Patients who had undergone IVF/ICSI-ET treatment were divided into two groups:unilateral orchidopexy group(n=52)and bilateral orchidopexy group(n=39).The basic conditions were compared:age,infertility time,sperm,conception condition,ovulation promotion and pregnancy outcome.Results:The sperm concentration and viability of bilateral orchidopexy group were significantly lower than those of unilateral group(both P<0.001).The fertilization rate of IVF and normal fertilization rate of IVF in bilateral orchidopexy group were also significantly lower than those in unilateral group(both P<0.001),but there was no significant difference in fertilization rate of ICSI and normal fertilization rate between the two groups.There was no significant difference in the number of top-quality embryos,clinical pregnancy rate and live delivery rate between the two groups.Conclusion:Compared with unilateral cryptorchidism,bilateral cryptorchidism significantly reduces sperm quality and fertilization ability,but ICSI can make up for the defect of fertilization and significantly improve the pregnancy outcome.

关 键 词：隐睾症 隐睾下降固定术 辅助生殖 体外受精/卵泡浆内单精子注射授精-胚胎移植 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]