青风藤安全性研究进展  

Research Progress on the Safety of Caulis Sinomenii

作　　者：郑湘锦 任利文 李婉[1] 王金华[1] 杜冠华[1] ZHENG Xiangjin;REN Liwen;LI Wan;WANG Jinhua;DU Guanhua(Key Laboratory of Drug Target Researchand Drug Screen of Beijing City , Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050, China)

机构地区：[1]药物靶点研究与新药筛选北京市重点实验室中国医学科学院北京协和医学院药物研究所

出　　处：《医药导报》2019年第11期1430-1433,共4页Herald of Medicine

基　　金：中国医学科学院协同创新工程(2016-I2M-3-007);国家科技部十三五重大新药创制(2018ZX09711001-005-025)

摘　　要：青风藤是防己科植物青藤及毛青藤的干燥藤茎,具有降压、抗心律失常、抗炎和抗肿瘤等作用。该文通过查阅文献并结合现代药理研究,分析青风藤的毒性以及引起毒性反应的物质基础和分子机制,评价青风藤毒性反应与药效活性的关系,分析毒性反应的主要临床表现及对策,以期为科学认识和临床合理应用青风藤提供参考。Caulis Sinomenii is a kind of traditional Chinese medicine which is dry cane of Sinomenium acuturn(Thunb.) Rehd et Wils. Or Sinamenium acutum(Thunb.) Rehd.et Wils.var.cinereum Rehd.et Wils.Caulis Sinomenii has many including antihypertensive, anti-arrhythmia,anti-inflammatory and anti-cancer effects. In this paper, we described toxicity caused by Caulis Sinomenii, analyzed material basis and molecular mechanism of its toxic reaction, introduced the main clinical manifestations and countermeasures of Caulis Sinomenii and evaluated the relationship between the toxic reaction and pharmacological activity.The review will provide a knowledge of its toxicity and a suggestion for more appropriate clinical use of Caulis Sinomenii.

关 键 词：青风藤 青藤碱 毒性反应 药效活性 

分 类 号：R286[医药卫生—中药学] R969[医药卫生—中医学]