冠心病患者血清SOD检测的临床意义  

Clinical significance of serum SOD in patients with coronary heart disease

作　　者：卢彦娜 彭建军 LU Yanna;PENG Jianjun(Department of Cardiology, Shougang Hospital, Peking University, Beijing 100041, China;Department of Cardiology, Beijing Shijitan Hospital,Capital medical university,Beijing 100038, China)

机构地区：[1]北京大学首钢医院心血管内科,北京100041 [2]首都医科大学附属北京世纪坛医院心血管内科,北京100038

出　　处：《河南大学学报（医学版）》2019年第3期201-203,共3页Journal of Henan University:Medical Science

摘　　要：〔目的〕旨在分析冠心病患者血清超氧化物歧化酶(SOD)与冠状动脉病变程度的相关性。〔方法〕选择2017年5月至2018年3月在心内科疑诊为冠心病行冠状动脉造影的患者240例。根据冠脉造影结果分为单支病变组、双支病变组和三支病变组,同期行冠脉造影正常者为正常组。收集患者一般临床资料,检测并分析患者血清SOD水平。〔结果〕正常组、单支病变组、双支病变组和三支病变组血清SOD水平依次下降,三支病变组血清SOD水平明显低于正常组及单支病变组(P<0.05)。双元Logistic回归分析发现年龄、性别、吸烟史、血清SOD水平与冠脉病变程度相关(P<0.05),多元Logistic回归分析在校正了年龄、性别、吸烟史等因素影响后血清SOD水平下降仍为冠脉病变程度的独立危险因素(P<0.05,OR 0.349,95%可信区间0.145~0.845)。〔结论〕冠心病患者血清SOD水平与冠脉病变支数呈负相关,检测血清SOD水平对评估冠心病患者冠脉病变程度具有一定的指导意义。〔Objective〕To investigate the relationship between the level of superoxide dismutase ( SOD) and the severity of coronary artery lesions in patients with coronary artery disease( CHD).〔Methods〕240 patients with suspected coronary heart disease who undergo coronary angiography in the department of cardiology from May 2017 to March 2018 were selected. According to the results of coronary angiography, the patients were divided into the single-vessel lesion group, the double-vessel lesion group and the three-vessel lesion group. Normal coronary angiography was the normal group. General clinical data were collected, and serum SOD levels were detected and analyzed.〔Results〕The serum SOD levels of the normal group, the single- vessel lesion group, the double-vessel lesion group and the three-vessel lesion group decreased successively, and the serum SOD levels in three-vessel lesion group were significantly lower than those in normal group and single-vessel lesion group ( P <0. 05). Binary Logistic regression analysis found that age, gender, history of smoking and the serum SOD level were correlated with the severity of coronary artery ( P < 0. 05). After adjusting for age, gender, smoking history and other factors, the decline of the serum SOD level was still an independent risk factor for the severity of coronary artery ( P < 0. 05, OR 0. 349,95% confidence interval 0. 145 ~0. 845).〔Conclusion〕The SOD level in patients with CHD is negatively correlated with the number of coronary stenosis. The detection of serum SOD level has certain guiding significance for the evaluation of the severity of coronary artery in patients with coronary artery disease.

关 键 词：冠心病 冠脉造影 超氧化物歧化酶 

分 类 号：R541.4[医药卫生—心血管疾病]