抗生素耐药性研究进展  

Progress of solutions against antibiotic resistance

作　　者：陆继爽 李波 单春乔 冯柳柳 王业华 刘艳 LU Ji-shuang;LI Bo;SHAN Chun-qiao;FENG Liu-liu;WANG Ye-hua;LIU Yan(Jiangsu Sanyi Research Quality Control Center,Pizhou,Jiangsu 221300,China;Panjin Veterinary drug and Feed Control Institute ,Panjin ,Liaoning 124010 ,China;Dalian Sanyi Bioengineering Research Institute ,Dalian ,Liaoning 116036 ,China)

机构地区：[1]江苏三仪科研质量控制中心,江苏邳州221300 [2]盘锦市兽药饲料监察所,辽宁盘锦124010 [3]大连三仪生物工程研究所,辽宁大连116036

出　　处：《中国兽医学报》2019年第10期2088-2095,共8页Chinese Journal of Veterinary Science

基　　金：甘井子区科技计划资助项目(2017SW131C3018)

摘　　要：抗生素耐药性是当今社会面临的最严峻挑战之一,细菌已经进化出多种机制得以在诸多抗生素中存活。因此,迫切需要寻找新的药物研发途径,理想的药物靶标与代谢和压力相关,而由信号核苷酸(p)pp Gpp调节的严谨反应是有效的靶标之一,抑制该途径会降低致病细菌存活率。最近设计的(p)pp Gpp小分子类似物,在抑制细菌生长和生物膜产生方面取得令人满意的结果。此外,抗菌肽、小RNA和核糖开关以及抗生素佐剂等在耐药性细菌感染方面也有很好的应用前景,本研究对目前抗生素耐药性研究进展加以总结。Antibiotic resistance is one of the most serious challenges which the world is facing currently.The number of people succumbing to drug-resistant infections is increasing every day,but the rate of drug discovery has failed to match the requisite demands.Bacteria have evolved multiple mechanisms to survive under the widely used condition of these antibiotics.Consequently,there is an urgent necessity to target auxiliary pathways for the discovery of new drugs.Metabolism-related and stress-associated pathways are ideal in this regard.The stringent response pathway regulated by the signaling nucleotides(p)pp Gpp is an attractive target as inhibition of the pathway would in turn decrease the persistence and long-term survival of pathogenic bacteria.The research focued on the recent design of small molecule analogues of(p)pp Gpp that have yielded promising results in terms of growth and biofilm inhibition.Additionally,discussed how targeting antimicrobial peptides,small RNAs and riboswitches as well as antibiotic adjuvants,would help to combat drug-resistant infections in the near future.

关 键 词：抗生素耐药性 严谨反应抑制剂 抗菌肽 小RNA和核糖开关 细菌代谢 抗生素佐剂 

分 类 号：Q939.92[生物学—微生物学] S859.796[农业科学—临床兽医学]