纳米材料在肿瘤核素内照射增敏治疗中的应用  

Application of nanomaterials in enhancing internal radiotherapy of radionuclide for cancer

作　　者：苏维维 王涛 左长京 Su Weiwei;Wang Tao;Zuo Changjing(Department of Nuclear Medicine, Changhai Hospital, Navy Medical University, Shanghai 200433, China)

机构地区：[1]海军军医大学附属长海医院核医学科,上海200433

出　　处：《中华核医学与分子影像杂志》2019年第10期632-635,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金(81471714,81871390).

摘　　要：放射性核素对肿瘤的治疗效果与其在肿瘤部位的聚集、滞留时间及瘤内分布等密切相关,此外还受肿瘤自身辐射抗性、乏氧微环境的影响。纳米材料具有特殊的尺寸效应和表面易被功能化修饰的特点,不仅可以作为载体将核素靶向运输到肿瘤,其连接核素后还可与化疗、热疗、光动力学疗法等产生协同治疗作用,或通过改善肿瘤乏氧微环境来降低辐射抗性,最终达到辐射增敏的目的。该文综述了纳米材料在增强肿瘤核素内照射疗效中的应用。The therapeutic efficiency of radionuclides for cancer is closely related to the accumulation level, residence time and distribution in tumor, and is also influenced by the radiation resistance and hypoxia microenvironment of tumor. Nanomaterials, with a series of characteristics including special dimension effect and functionally modifiable surface, can not only work as the isotopic carrier to transport nuclide into tumor, but also combine with chemical, thermal or photodynamic therapies to generate synergistic therapeutic effect or destroy the hypoxic microenvironment of tumor to reduce radiation resistance, thus achieving the radiosensitization effect. This article reviews the application of nanomaterials in enhancing the therapeutic efficiency of radionuclide for cancer.

关 键 词：肿瘤 放射疗法 放射性同位素 辐射增敏药 纳米结构 发展趋势 

分 类 号：R730[医药卫生—肿瘤] TB38[医药卫生—临床医学]