颅脑fMRI及脊髓弥散张量成像对脊髓型颈椎病患者术后脊髓功能恢复的预测价值分析  

Value of brain fMRI and spine DTI in predicting functional outcomes for patients with cervical spondylotic myelopathy

作　　者：宋彦澄 康立清[2] 申沧海[3] 付兰 刘凤海 冯永健[3] Song Yancheng;Kang Liqing;Shen Canghai;Fu Lan;Liu Fenghai;Feng Yongjian(Department of MRI, Cangzhou Central Hospital, Cangzhou 061000, China;Department of MRI, Cangzhou Central Hospital, Cangzhou 061000, China;Department of Orthopedic Surgery, Cangzhou Central Hospital, Cangzhou 061000, China)

机构地区：[1]天津医科大学沧州市中心医院教学医院,沧州061000 [2]沧州市中心医院磁共振成像科,沧州061000 [3]沧州市中心医院骨四科,沧州061000

出　　处：《中华物理医学与康复杂志》2019年第9期651-656,共6页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的探讨颅脑fMRI及脊髓弥散张量成像(DTI)量化参数与脊髓型颈椎病(CSM)患者术前脊髓功能的相关性及对CSM术后脊髓功能恢复的预测价值.方法选取2018年1月至2018年12月期间行手术治疗的CSM患者87例(纳入CSM组)及年龄、性别、受教育程度与之匹配的健康志愿者38例(纳入对照组).所有患者于术前及术后6个月时均进行fMRI和DTI扫描,对照组于入选时进行fMRI和DTI扫描;所有对象的fMRI动作任务均为右手对指动作.入选CSM患者术后均给予系统康复干预.术前及术后6个月时采用日本骨科学会评分(JOA)系统评估患者脊髓神经功能情况,术后6个月随访时将JOA评分改善率<50%的CSM患者视为术后恢复不良.结果术前CSM组左侧中央前回(PrCG)激活体积(VOA)较对照组显著增加(P<0.05),左侧中央后回(PoCG)VOA值与对照组无显著差异(P>0.05),脊髓受压节段FA值较对照组显著降低(P<0.05).术后6个月随访时发现CSM患者左侧PrCG-VOA值较术前显著减小(P<0.05),FA值较术前显著增加(P<0.05).通过相关性分析发现,术前VOA比值(PrCG/PoCG)、PrCG-VOA、PoCG-VOA及FA值与术前JOA评分、术后JOA评分改善率间均具有显著相关性(P<0.05).通过受试者工作特征曲线(ROC)分析,发现fMRI及DTI量化参数预测术后恢复不良的效能均显著优于常规MRI参数;多因素Logistic回归分析显示VOA比值与FA值是预测CSM术后恢复不良的独立危险因素.结论与常规MRI比较,颅脑fMRI及脊髓DTI能更好地预测CSM术后脊髓功能恢复情况,为科学制订术后康复方案提供参考资料.To explore the correlations relating functional MRI (fMRI) and diffusion tensor imaging (DTI) parameters with pre-operative neurological status and post-operative outcomes for patients with cervical spondylotic myelopathy (CSM). Methods Eighty-seven CSM patients treated with surgical decompression and 38 healthy counterparts were enrolled as the CSM and control groups respectively. DTI and fMRI of the cervical spine were performed while the subjects performed a finger-tapping task with their right hands before the operation and 6 months later. The control group was evaluated only when they were enrolled. All of the patients were given systematic rehabilitation treatment after the surgery. The Japanese Orthopaedic Association (JOA) scoring system for CSM was used to evaluate neurological status, and a JOA recovery rate <50% was defined as a poor recovery. Results Compared with the healthy controls, the pre-operative patients showed significantly higher volume of activation (VOA) in the left precentral gyrus (PrCG), but that had decreased significantly 6 months after the surgery. Before the surgery, the patients′ fractional isotropy (FA) was significantly less than that of the controls, but it had increased significantly 6 months after the operation. There was no difference in VOA in the left postcentral gyrus (PoCG) between the CSM patients and the controls before the surgery. The VOA ratio (PrCG/PoCG), VOA-PrCG, VOA-PoCG and FA were significantly correlated with both the JOA scores and recovery rates. Receiver operating characteristic (ROC) curve analyses were performed for the predictive ability with respect to surgical outcomes. The largest area under the ROC curve was observed for the VOA ratio (0.805), followed by FA (0.740), and the VOA-PrCG (0.715). The fMRI and DTI showed better potential for predicting functional outcomes than with standard MRI parameters. Multivariate logistic regression revealed that the VOA ratio and FA were independently associated with poor outcomes. Conclusions fMRI and DTI parame

关 键 词：脊髓型颈椎病 功能性磁共振 皮质重构 弥散张量成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R681.55[医药卫生—诊断学]