Immunoregulatory effects of Tripterygium wilfordii Hook Fand its extracts in clinical practice  

作　　者：Dan Luo Zhengyun Zuo Hongyan Zhao Yong Tan Cheng Xiao 

机构地区：[1]Traditional Chinese Medicine Hospital of Changping District,Beijing 102200,China [2]Institute of Clinical Medicine,China-Japan Friendship Hospital,Beijing 100029,China [3]Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China [4]Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100070,China [5]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100070,China

出　　处：《Frontiers of Medicine》2019年第5期556-563,共8页医学前沿（英文版）

基　　金：the National Natural Science Foundation of China (Nos.81673844, 81573845, 81373773, and 81760838);the Beijing Natural| Science Foundation (No.7142144);China Scholarship Council Fund (No.201609110029);the Interna-tional Cooperation Project of the State Administration of Traditional Chinese Medicine (No.GZYYGJ2017014);the International Cooperation Project of the Ministry of Science and Technology (No.2014DFA31490).

摘　　要：Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells;ratio of T cell subsets;inflammatory response of monocytes, macrophages, and immunoglobulins;and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

关 键 词：TRIPTERYGIUM mlfordii HOOK F IMMUNOREGULATION clinical studies 

分 类 号：R[医药卫生]