自拟黄芪附子方对CRF维持性血液透析患者治疗效果和生活质量的影响  

Effect of self-made Huangqi Fuzi prescription on therapeutic effect and quality of life of CRF patients with maintenance hemodialysis

作　　者：杨妮 YANG Ni(Yuyang District People's Hospital, Yulin 719000, China)

机构地区：[1]榆阳区人民医院

出　　处：《中国实用医药》2019年第29期20-22,共3页China Practical Medicine

摘　　要：目的探讨自拟黄芪附子方用于慢性肾功能衰竭(CRF)维持性血液透析患者的治疗效果及对氧化应激、微炎症反应和生活质量的影响.方法 80例行维持性血液透析的CRF患者,随机分为观察组及对照组,每组40例.观察组患者给予自拟黄芪附子方治疗,对照组患者未予以自拟黄芪附子方治疗.比较两组患者治疗前后的氧化应激指标[超氧化物歧化酶(SOD)、丙二醇(MDA)、总抗氧化能力(T-AOC)],微炎症指标[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、人脂蛋白-a(LP-a)]水平及治疗后的生活质量情况.结果治疗后,两组患者的SOD、T-AOC水平均较本组治疗前升高,MDA水平均较本组治疗前降低,且观察组改善程度优于对照组,差异均具有统计学意义(P<0.05).两组患者的hs-CRP、IL-6、TNF-α、LP-a水平均较本组治疗前降低,且观察组降低程度优于对照组,差异均具有统计学意义(P<0.05).观察组患者的症状与不适、肾脏疾病对生活的影响、工作状况、性功能评分分别为(67.34±8.74)、(73.22±6.95)、(68.54±5.47)、(5.98±1.05)分,均高于对照组的(49.38±6.57)、(58.66±5.96)、(61.32±5.21)、(3.66±0.73)分,差异均具有统计学意义(P<0.05);两组患者的肾脏疾病对生活的负担、认知能力、社交质量评分比较,差异无统计学意义(P>0.05).结论自拟黄芪附子方可有效改善维持性血液透析CRF患者氧化应激状态和微炎症反应,提高患者生活质量.Objective To discuss the therapeutic effect of self-made Huangqi Fuzi prescription on therapeutic effect and quality of life of chronic renal failure(CRF) patients with maintenance hemodialysis and its influence on oxidative stress, microinflammation and quality of life. Methods A total of 80 CRF patients with maintenance hemodialysis were randomly divided into observation group and control group, with 40 cases in each group. The observation group received self-made Huangqi Fuzi prescription, and the control group received no self-made Huangqi Fuzi prescription. Comparison was made on indicators of oxidative stress [superoxide dismutase(SOD), propylene glycol(MDA), total antioxidant capacity(T-AOC)], microinflammatory markers [high-sensitivity C-reactive protein(hs-CRP), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), human lipoprotein-a(LP-a)] before and after treatment and quality of life after treatment between the two groups. Results After treatment, the SOD and T-AOC levels in two groups were higher than those before treatment,and the improvement degree in the observation group was better than that in the control group. Their difference was statistically significant(P<0.05). The hs-CRP, IL-6, TNF-α and LP-a in both groups was lower than those before treatment, and the decline degree in the observation group was better than that in the control group. Their difference was statistically significant(P<0.05). The symptoms and discomfort, the impact of kidney disease on life, work status, sexual function score were(67.34±8.74),(73.22±6.95),(68.54±5.47) and(5.98±1.05) points respectively in the observation group, which was higher than(49.38±6.57),(58.66±5.96),(61.32±5.21) and(3.66±0.73) points in the control group, and their difference was statistically significant(P<0.05). There was no statistically significant difference in burden of kidney disease on life, cognitive ability and social quality score between the two groups(P>0.05). Conclusion Self-made Huangqi Fuzi prescription can effectively impr

关 键 词：自拟黄芪附子方 慢性肾功能衰竭 维持性血液透析 

分 类 号：R277.5[医药卫生—中医学]