粒细胞输注的研究现状  

Research status of granulocyte transfusions

作　　者：张梦营 王化泉[1] 邵宗鸿[1] Zhang Mengying;Wang Huaquan;Shao Zonghong(Department of Hematology, Tianjin General Hospital, Tianjin Medical University, Tianjin 300052, China)

机构地区：[1]天津医科大学总医院血液科,300052

出　　处：《国际输血及血液学杂志》2019年第5期380-386,共7页International Journal of Blood Transfusion and Hematology

基　　金：国家自然科学基金(81370607、81170472);天津市科技重大专项与工程(18ZXDBSY00140).

摘　　要：中性粒细胞为人体防御细菌与真菌感染最为重要的细胞之一。接受放、化疗或者造血干细胞移植(HSCT)的急性白血病患者,以及重型再生障碍性贫血(SAA)患者均会出现重度粒细胞缺乏,并且持续时间较长,在此期间患者可能发生重症细菌与真菌感染。尽管目前广谱抗菌药物与粒细胞集落刺激因子(G-CSF)已被广泛应用于临床,但是粒细胞缺乏期间发生的重症感染,仍然是导致患者住院时间延长、器官损伤,甚至死亡的因素之一。骨髓粒细胞造血功能的恢复为成功控制感染的关键,对于粒细胞减少,特别是粒细胞缺乏伴重症感染患者,粒细胞输注成为一种辅助治疗手段。为了正确认识粒细胞输注的作用与适应证,笔者拟就粒细胞的采集技术、粒细胞输注的疗效及不良反应进行介绍。Neutrophils are one of the most important cells in the body against bacterial and fungal infections. Patients with acute leukemia who received radiotherapy, chemotherapy or hematopoietic stem cell transplantation (HSCT), and with severe aplastic anemia (SAA), can occur with severe neutropenia that lasts longer, during which severe bacterial and fungal infections can occur. Despite the use of broad-spectrum antibacterial agents and granulocyte colony-stimulating factor (G-CSF), severe infections during neutropenia still lead to prolonged hospital stay, organ damage, and even death of patients. The recovery of bone marrow granulocyte hematopoiesis is the key to successful infection control. For patients with severe infections of granulocytopenia, especially agranulocytosis, granulocyte transfusions is a means of adjuvant therapy. In order to understand the role and indications of granulocyte transfusions, the article intends to introduce the collection technology of granulocyte, therapeutic effect and adverse reactions of granulocyte transfusions.

关 键 词：中性粒细胞减少 粒细胞缺乏 粒细胞集落刺激因子 感染 粒细胞输注 中性粒细胞功能障碍 

分 类 号：R457.1[医药卫生—治疗学]