恶性淋巴瘤化疗后合并足细胞内陷病一例报告  

Malignant lymphoma complicated with podocytic infolding glomeruopathy after chemotherapy: a case report

作　　者：李娟[1] 卢婉君 龚书豪 王缨[1] LI Juan;LU Wan-jun;GONG Shu-hao;WANG Ying(Department of Nephropathy, the First Affiliated Hospital of Nanchang University, Jiangxi 330006, China)

机构地区：[1]南昌大学第一附属医院肾脏内科

出　　处：《天津医药》2019年第10期1089-1091,共3页Tianjin Medical Journal

摘　　要：足细胞内陷病(PIG)是近年发现的罕见的肾小球疾病,其诊断主要依赖于肾脏病理表现,目前对此病的相关临床病例报道尚少见。本文介绍1例因恶性淋巴瘤化疗后导致的PIG,为46岁女性患者,弥漫大B细胞淋巴瘤化疗后出现蛋白尿阳性、双下肢轻度水肿。相关实验指标符合肾病综合征的诊断。肾组织活检结果符合足细胞内陷性肾小球病。本文通过分析该病例及查阅足细胞内陷性肾小球病的相关临床病例报道,探讨PIG的相关发病机制。Podocytic infolding glomerulopathy (PIG) is a rare glomerular disease found in recent years. Its diagnosis mainly depends on pathological features. At present, there are relatively few clinical cases of this disease. This paper introduces a case of PIG caused by chemotherapy of malignant lymphoma. A 46-year-old female patient showed positive proteinuria and mild edema of lower limbs after chemotherapy for diffuse large B lymphoma. The related experimental data were in accordance with the diagnosis of nephrotic syndrome. The renal biopsy was performed. The pathological diagnosis was in consistent with PIG. The purpose of this article was to analyze the pathogenesis of PIG and review the clinical reports of PIG.

关 键 词：足细胞内陷病 淋巴瘤化疗后 足细胞损伤 补体激活 

分 类 号：R692.6[医药卫生—泌尿科学]