Klotho抑制肾间质纤维化的作用及机制  

Effect and Mechanism of Klotho against Renal Interstitial Fibrosis

作　　者：缪静龙[1] 刘其锋[1] MIU Jingling;LIU Qifeng(Department of Nephrology ,Kunshan First People′s Hospital Affiliated to Jiangsu University,Kunshan 215300,China)

机构地区：[1]江苏大学附属昆山医院肾脏内科

出　　处：《医学综述》2019年第20期3985-3990,共6页Medical Recapitulate

摘　　要：Klotho是新发现的抗衰老因子,主要表达于肾脏,对肾脏而言具有广泛的保护作用,其中对肾间质纤维化(RIF)的抑制作用是Klotho发挥肾脏保护作用的一个重要机制。Klotho可通过调控转化生长因子-β1(TGF-β1)、Wnt/β-联蛋白(β-catenin)、肾小管上皮细胞间质转化(EMT)、肾素-血管紧张素系统(RAS)、成纤维细胞生长因子2(FGF-2)、内质网应激(ERS)等多种与RIF相关的信号通路,多靶点抑制RIF的发生发展。因此,Klotho被认为是新的RIF抑制因子,以Klotho为干预靶点,可以为将来RIF的防治提供新思路。Klotho is recently identified as an anti-aging factor and it is mainly located in the kidney and has exhibited various renal-protective effects including inhibition of renal interstitial fibrosis( RIF). Nowadays Klotho is believed to inhibit RIF by targeting transforming growth factor β1( TGF-β1),Wnt/β-catenin,epithelial-mesenchymal transition( EMT),reninangiotensin system( RAS),fibroblast growth factor-2( FGF-2) and endoplasmic reticulum stress( ERS) signaling involved in RIF. Klotho has been regarded as a novel factor for RIF inhibition and targeting Klotho may provide new ideas for the prevention and treatment of RIF in future.

关 键 词：肾间质纤维化 KLOTHO 通路 

分 类 号：R692.5[医药卫生—泌尿科学]