某院2100例药品不良反应报告回顾性分析  

Retrospective Analysis of 2 100 Cases of Adverse Drug Reaction in a Hospital

作　　者：窦芳 恽艳琴 陈钰 楚建杰 李韦韦 赵先 王婧雯 文爱东 Dou Fang;Yun Yanqin;Chen Yu;Chu Jianjie;Li Weiwei;Zhao Xian;Wang Jingwen;Wen Aidong(Department of Pharmacy,Xijing Hospital,Air Force Military Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学西京医院药剂科

出　　处：《药物流行病学杂志》2019年第10期673-676,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:了解某院2016~2018年药品不良反应(ADR)的发生特点和规律,为ADR监测和临床安全用药提供参考。方法:收集该院2016~2018年上报的2100份ADR报告,按患者性别、年龄、药物种类、给药途径、临床表现、反应分级及转归情况等进行回顾性分析。结果:ADR报告中,男1119例(53.28%),女981例(46.72%);患者年龄分布以45~60岁最多,共820例(39.05%)。一般的ADR为2022例,新的ADR13例,严重的ADR64例,新的和严重的ADR仅有1例。医生上报ADR551例,护士上报171例,临床药师上报1378例。致ADR的怀疑药物主要为抗感染药物(396例,18.86%),给药方式以静脉滴注占比最高(1104例,52.59%);累及系统/器官以消化系统受损为主(771例,36.71%)。结论:ADR发生与多种因素有关,应加强ADR监测,减少ADR的发生,促进临床用药安全。Objective: To investigate the characteristics and regularities of adverse drug reactions ( ADR) in our hospital from 2016 to 2018, improve the ADR monitoring work and provide reference for rational drug use in clinic. Methods : Retrospectively analysis 2 100 cases of ADR reports collected in our hospital from 2016 to 2018 which were performed according to patients gender and age, categories of drugs, route of administration, main clinical manifestations ,reaction grading and outcome. Results : Among the 2 100 ADR reports, the number of male patients and female patients were 1 119 cases ( accounting for 53. 28%) and 981 cases ( accounting for 46. 72%),respectively. The highest proportion of ADR occurred in 45-60 year old patients ( 820 cases,39. 05%). General ADRs reached 2 022 cases, and new ADRs reached 13 cases, serious ADRs reached 64 cases,and new and severe ADR accounted for only 1 case. The doctor reported 551 cases of ADR, the nurse reported 171 cases of ADR, and the clinical pharmacist reported 1 378 cases of ADR. The anti-infective agent caused the highest proportion of ADR ( 396 cases, 18. 86%). The most ADR reports were caused by intravenous drip administration ( 1 104 cases, 52. 59%). The main organs or systems involved in ADR were the gastrointestinal system (771 cases, 36. 71%). Conclusion : The multiple factors may lead to high frequency of ADR. Therefore this hospital should pay attention to the management of these drugs, active drug monitoring, thereby reducing the incidence of adverse reactions ,the promotion of rational drug use.

关 键 词：药品不良反应 监测 报告 安全用药 

分 类 号：R951[医药卫生—药学]