血清Copeptin、HIF-1α、CT-1水平与新生儿败血症心肌损伤的相关性分析  

Correlation analysis of serum copeptin, HIF-1α, CT-1 levels and myocardial injury in neonatal septicemia

作　　者：孙瑞雪[1] 姜泓[1] 张宁梅 雷娟娟[1] SUN Ruixue;JIANG Hong;ZHANG Ningmei;LEI Juanjuan(Department of Pediatrics,Yanan 716000,Shaanxi,China;Clinical laboratory,Affiliated Hospital of Yan??an University,Yanan 716000,Shaanxi,China)

机构地区：[1]延安大学附属医院新生儿科,陕西 延安 716000 [2]延安大学附属医院检验科,陕西 延安 716000

出　　处：《中南医学科学杂志》2019年第5期462-464,共3页Medical Science Journal of Central South China

摘　　要：探讨新生儿败血症和肽素(Copeptin)、缺氧诱导因子-1α(HIF-1α)、心肌营养素1(CT-1)水平与心肌损伤的相关性。选取本院收治的150例新生儿败血症患儿分为心肌损伤组(n=82)和非心肌损伤组(n=68)。比较各组间血清Copeptin、HIF-1α、CT-1水平。结果显示,与非心肌损伤组比较,心肌损伤组血清肌酸激酶心肌同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)和心脏型脂肪酸结合蛋白(H-FABP)水平,血清Copeptin、HIF-1α、CT-1水平显著升高(P<0.05)。经过Spearson相关性分析,Copeptin、HIF-1α、CT-1水平与新生儿败血症合并心肌损伤患儿CK-MB、cTnI、H-FABP均呈正相关(P<0.05)。结果提示,血清Copeptin、HIF-1α、CT-1水平对患儿的病情评估和预后有潜在临床价值。To investigate the correlation between copeptin, hypoxia inducible factor-1α(HIF-1α), myocardial nutrient 1(CT-1) and myocardial injury. The subjects of150 neonates with septicemia were selected and divided into two groups: myocardial injury group(n=82) and non-myocardial injury group(n=68). The serum levels of Copeptin, HIF-1α and CT-1 and the markers of cardiac function injury were compared in each group. The serum CK-MB, cTnI, H-FABP level in myocardial injury group were significantly higher than that in non myocardial injury group(P<0.05). The serum levels of Copeptin, HIF-1α and CT-1 in myocardial injury group were significantly higher than those in non myocardial injury group(P<0.05). By Spearson correlation analysis, the levels of Copeptin, HIF-1 α and CT-1 were positively correlated with CK-MB, cTnI, H-FABP in neonates with septicemia and myocardial injury(P<0.05). The levels of serum Copeptin, HIF-1 α and CT-1 have potential clinical value for the evaluation and prognosis of neonatal septicemia.

关 键 词：和肽素 缺氧诱导因子-1Α 心肌营养素1 新生儿败血症 

分 类 号：R722[医药卫生—儿科]