止血药物在体外循环心脏外科手术中的血液保护作用  

Blood conservation effect of hemostatic drugs in cardiac surgery under cardiopulmonary bypass

作　　者：李冬梅[1] 李文志[1] Li Dongmei;Li Wenzhi(Department of Anesthesiology, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Key Laboratory of Anesthesiology and Intensive Care Research & Key Laboratory for Basic Theory and Application of Anesthesiology of the Heilongjiang Higher Education Institution, Harbin 150086, China)

机构地区：[1]哈尔滨医科大学附属第二医院麻醉科,黑龙江省麻醉与危重病学重点实验室,黑龙江省普通高等学校麻醉基础理论与应用研究重点实验室,150086

出　　处：《国际麻醉学与复苏杂志》2019年第8期785-788,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：CPB心脏外科手术可导致血液的大量丢失。止血药物既可预防失血又可治疗出血,是常用的血液保护药物。文章通过综述近年文献,介绍常用的几种止血药物在CPB心脏外科手术中的应用,并分析其优缺点,为围手术期血液保护提供参考。虽然近年来血液保护药物的应用不断更新,但其用药剂量、给药时机及途径还需进一步的文献支持。Cardiac surgery under cardiopulmonary bypass can lead to a large loss of blood. Hemostatic drugs can not only prevent blood loss but also treat bleeding, They are commonly used blood conservation drugs. This article overviews the published literatures, introduces the application of several hemostatic drugs in cardiac surgery and analyzes their advantages and defects and provides reference for perioperative blood conservation. Although the application of blood conservation drugs have been updated in recent years, their dosage, timing and route of administration need further literature support.

关 键 词：血液保护 体外循环 止血药物 抑肽酶 氨甲环酸 氨甲苯酸 氨基己酸 

分 类 号：R654.2[医药卫生—外科学]