C型利钠肽在循环系统作用的研究进展  

Advances in the role of C-type natriuretic peptides in the circulatory system

作　　者：高晓薇[1] 覃罡[1] 李龙艳[1] 张重[1] 叶治[1] 王锷[1] Gao Xiaowei;Qin Gang;Li Longyan;Zhang Zhong;Ye Zhi;Wang E(Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China)

机构地区：[1]中南大学湘雅医院麻醉科,长沙410008

出　　处：《国际麻醉学与复苏杂志》2019年第8期794-797,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：C型利钠肽(C-type natriuretic peptide,CNP)作为利钠肽家族(natriuretic peptides,NPs)一员,是心血管系统中具有血流动力学相关和抗重塑作用的一种多肽类激素。CNP由于其利尿、利钠、血管舒张、抗增殖和抗肥厚效应,可能与主要心血管疾病(如心力衰竭、冠状动脉疾病、肺动脉高压、左心室肥大和脑血管意外)的致病机制相关。文章通过对CNP的结构、特点、代谢、受体以及相关信号通路的阐述,针对CNP在循环系统和心血管疾病的作用进行综述,有助于进一步认识CNP在循环系统中的重要作用。新的基于CNP的治疗策略目前仍处于研究初期阶段,它们有望为未来的肺动脉高压、心力衰竭、冠状动脉疾病预防和治疗做出贡献。C-type natriuretic peptide (CNP), one of the natriuretic peptides (NPs) family, plays an important role in mediating cardiovascular homeostasis and maintaining the cardiac structure. As a remarkable polypeptide hormone, CNP has been demonstrated capacilities to regulate fluid volume, water and salt balance. CNP also possesses vasorelaxing, anti-proliferation, and anti-hypertrophic properties, which may be related to heart failure, coronary artery disease, pulmonary artery hypertension, left ventricular hypertrophy and cardiocerebral events. In the review, we described CNP structure, characteristics, receptors, and relative signaling pathway. This review is aimed to summarize the role of CNP in the circulation system and cardiovascular system. Furthermore, CNP-based drugs may provide a promising therapeutic strategy for preventing and treating heart failure, pulmonary artery hypertension and coronary artery disease.

关 键 词：C型利钠肽 循环系统 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]