深圳市新生儿早产影响因素的病例对照研究  

Factors influencing preterm birth in Shenzhen city: a case-control study

作　　者：樊静洁[1] 刘世新[1] 林一才 FAN Jing-jie;LIU Shi-xin;LIN Yi-cai(Maternal and Child Health Care Hospital of Shenzhen City,Shenzhen,Guangdong 518017,China)

机构地区：[1]深圳市妇幼保健院

出　　处：《实用预防医学》2019年第11期1322-1325,共4页Practical Preventive Medicine

基　　金：深圳市卫生计生系统科研项目(项目编号:201607045)

摘　　要：目的探讨深圳市新生儿早产相关危险因素,为预防早产提供参考依据。方法在深圳市某妇幼保健院选取2015年1月1日-12月31日分娩的产妇和新生儿为研究对象,以妊娠满28周不足37周的200例新生儿母亲为病例组,妊娠满37周~42周的200例新生儿母亲为对照组。收集2014年1月1日-2015年12月31日SO2、NO2、PM10、PM2.5、CO和O3逐日浓度。运用logistic回归模型分析早产影响因素。结果 2014-2015年深圳市空气质量良好。病例组和对照组孕早期SO2暴露浓度分别为(10.00±5.10)μg/m3、(8.66±5.03)μg/m3,NO2暴露浓度分别为(38.23±15.98)μg/m3、(35.33±15.01)μg/m3,差异均有统计学意义(P<0.05);病例组和对照组孕晚期PM10暴露浓度分别为(54.26±28.00)μg/m3、(51.39±27.92)μg/m3,PM2.5暴露浓度分别为(32.96±19.20)μg/m3、(30.11±18.36)μg/m3,差异均有统计学意义(P<0.05)。病例组和对照组产妇年龄分别为(29.2±5.4)岁、(27.6±6.0)岁,家族早产史所占比例分别为38.5%、26.5%,大专及以上文化程度所占比例分别为62.5%、73.5%,差异均有统计学意义(P<0.05)。进一步进行早产影响因素的多因素logistic回归分析发现:产妇年龄(OR=1.009, 95%CI:1.002~1.018)、有家族早产史(OR=1.308,95%CI:1.019~1.714)、孕晚期PM2.5(OR=1.387,95%CI:1.112~1.579)、孕晚期PM10(OR=1.267,95%CI:1.108~1.531)、孕早期SO2(OR=1.118,95%CI:1.009~1.329)、孕早期NO2(OR=1.106,95%CI:1.009~1.273)对早产有影响。结论深圳市空气SO2、NO2、PM10、PM2.5污染、产妇年龄和家族早产史与早产有关。Objective To explore the risk factors related to preterm labor in Shenzhen city, and to provide references for preventing preterm birth. Methods The parturients and newborns who delivered in a maternal and child health care hospital in Shenzhen city from January 1 to December 31 in 2015 were selected as the research subjects. The mothers of 200 newborns born at 28 and less than 37 weeks’ gestation were taken as the case group, while the mothers of 200 newborns born at 37 and 42 weeks’ gestation were considered as the control group. The daily average concentration of air pollutants, including SO2, NO2, PM10, PM2.5, CO and O3, in Shenzhen city from January 1, 2014 to December 31, 2015 was collected. Logistic regression model was used to analyze the factors influencing preterm birth. Results The quality of air in Shenzhen city from 2014 to 2015 was good. Statistically significant differences were found in the exposure air concentration of SO2 in early pregnancy((10.00±5.10)μg/m3 vs.(8.66±5.03)μg/m3), the exposure air concentration of NO2 in early pregnancy((38.23±15.98)μg/m3 vs.(35.33±15.01)μg/m3), the exposure air concentration of PM10 in late pregnancy((54.26±28.00)μg/m3 vs.(51.39±27.92)μg/m3) and the exposure air concentration of PM2.5 in late pregnancy((32.96±19.20)μg/m3 vs.(30.11±18.36)μg/m3) between the case group and the control group(all P<0.05). There were statistically significant differences in the maternal age((29.2±5.4) years old vs.(27.6±6.0) years old) and the proportion of mothers with a family history of preterm labor(38.5% vs. 26.5%) and the proportion of mothers with college education and above(62.5% vs. 73.5%) between the case group and the control group(all P<0.05). Multivariate logistic regression analysis showed that maternal age(OR=1.009, 95%CI:1.002-1.018), having a family history of preterm birth(OR=1.308,95%CI:1.019-1.714), PM2.5 in late pregnancy(OR=1.387, 95%CI:1.112-1.579), PM10 in late pregnancy(OR=1.267, 95%CI:1.108-1.531), SO2 in early pregnancy(OR=1.118, 95%CI:

关 键 词：早产 病例对照研究 空气污染 关系 

分 类 号：R722[医药卫生—儿科]