血红素加氧酶-1在感染性疾病中的作用及研究进展  

Role of heme oxygenase-1 in infectious disease and study progress

作　　者：王凡[1] 王宏娟[1] 徐世明[1] WANG Fan;WANG Hongjuan;XU Shiming(Teaching and Researching Section of Biochemistry and Molucular Biology,Yanjing Medical College,Capital Medical University,Beijing 101300,China)

机构地区：[1]首都医科大学燕京医学院生物化学与分子生物学教研室

出　　处：《重庆医学》2019年第20期3541-3544,共4页Chongqing medicine

基　　金：北京市自然科学基金项目(7132033);燕京医学院科研基金项目(19py01;18qdky04;19qdky01)

摘　　要：血红素加氧酶-1(HO-1)是机体内广泛存在的抗氧化防御酶。在正常生理状态下,HO-1的表达水平较低。在缺血、缺氧、炎症等多种应激状态下,HO-1可被诱导大量表达,进而在多种疾病中发挥细胞保护作用。但对于HO-1与感染性疾病的相关研究报道较少。现对HO-1在感染性疾病(细菌、真菌、寄生虫、病毒)中的作用进行综述。Heme oxygenase-1 (HO-1) is a kind of antioxidant defense enzymes,which widely exists in the body.Under normal physiological condition,the expression level of HO-1 is low.HO-1 can be induced to express in large quantities under various stress states,thus plays the cellular protective effect in various diseases.The relevant research reports of HO-1 and infectious diseases are less.This paper reviews the role of HO-1 in infectious diseases (bacteria,fungi,parasites,viruses).

关 键 词：血红素加氧酶-1 感染性疾病 细菌 真菌 寄生虫 病毒 

分 类 号：Q554[生物学—生物化学]