贵州省少数民族地区外出务工者乙型肝炎流行模式  

A study on epidemic model of hepatitis B virus in migrant workes in Guizhou minority areas

作　　者：宋文君 黄文湧 杨敬源 蒋芝月 汪俊华 官志忠 SONG Wen-jun;HUANG Wen-yong;YANG Jing-yuan;JIANG Zhi-yue;WANG Jun-hua;GUAN Zhi-zhong(Department of Epidemiology and Health Statistics, School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Health Development, Research Institute, Key Laboratory of Medical Molecular, Guizhou Medical University)

机构地区：[1]贵州医科大学公共卫生学院流行病与卫生统计学系环境污染与疾病监控教育部重点实验室贵州省卫生发展研究院贵州省医学分子生物学重点实验室

出　　处：《中华疾病控制杂志》2019年第10期1255-1259,共5页Chinese Journal of Disease Control & Prevention

基　　金：科技部“十二五”国家科技支撑计划(2013BAI05B03)~~

摘　　要：目的调查贵州少数民族地区外出务工人员乙肝流行模式特点,为乙肝的防控措施提供参考。方法采用多阶段分层整群抽样方法,对贵州少数民族地区雷山和荔波县分别抽取4个村为调查地点,对当地居民进行问卷调查和血清乙肝五项检测。结果本次调查贵州少数民族总人群1 629人,外出务工464人中乙肝感染率为44.8%、HBsAg携带率为8.4%、抗-HBs阳性率为28.0%、抗-HBc阳性率为25.6%。外出务工感染模式检出率(19.8%)低于非外出务工者(23.2%),但差异无统计学意义(P>0.05);外出务工者易感模式检出率为(52.2%)高于非外出务工者(43.4%),免疫模式检出率(28.0%)低于非外出务工者(33.4%),差异均具有统计学意义(均有P<0.05)。经多分类Logistic回归分析模型调整相关因素后,相对于非外出务工居民,外出务工仍为易感模式的影响因素(OR=1.568,95%CI:1.206~2.039)。结论贵州少数民族地区外出务工人员乙肝易感性相对较高,应大力加强对外出务工者乙肝疫苗免疫接种,提高其特异性免疫,以减少乙肝的感染与流行。Objective To research the prevalence model of hepatitis B virus in the minority areas of Guizhou and to provide reference for the prevention and control virus of hepatitis B virus. Methods Using multi-stage cluster simple random sampling, four villages were selected from Leishan and Libo counties in minority areas of Guizhou. Questionnaires were investigated by trained investigators and serum hepatitis B virus five-item test results were collected from the subjects. Results A total of 1 629 participants were surveyed, the outcome showed that migrant workers' infection rate of hepatitis B was 44. 8%, and the carrying rate of HBsAg was 8.4%. The positive rates of anti-HBs and anti-HBc were 28.0% and 25. 6% respectively. The infection model rate of migrant workers was 19. 8%, which was lower than that of non-migrant workers (23. 2%)(P >0. 05). The detection rate of susceptible model in migrant workers (52. 2%) was higher than that in non-migrant workers (43. 4%), while the detection rate of immune mode migrant workers (28. 0%) was lower than that in non-migrant workers (33. 4%), which the difference was statistically significant ( all P < 0. 05 ). After adjusted related factors by multivariate Logistic regression analysis model, migrant workers were still the influencing factors of vulnerability model ( OR = 1. 568, 95% CI:1. 206-2. 039) compared with non-migrant workers. Conclusion There was a high susceptibility to hepatitis B virus among migrant workers in minority areas of Guizhou, In order to reduce the infection and prevalence of hepatitis B virus, we should strengthen the immunization of hepatitis B vaccine to migrant workers and to improve their specific immunity.

关 键 词：乙型肝炎病毒 外出务工人口 贵州少数民族 易感模式 

分 类 号：R183[医药卫生—流行病学]