AOPP在狼疮肾炎患者中血清水平变化及其与疾病活动的相关性  

Changes of oxidative stress markers late oxidative protein products in serum of patients with lupus nephritis and its correlation with disease activity of lupus nephritis

作　　者：李松[1] 黄恩有 何建静[1] 邹凡[1] 罗仕云[1] 应晓洲[2] LI Song;HUANG Enyou;HE Jianjing;ZOU Fan;LUO Shiyun;YING Xiaozhoi(Department of Nephrology ,Chinese Peopled Liberation Army 923 Hospital,Nanning 530021,China;Department of General Surgery,Wenzhou Medical University ,Wenzhou 325000,Zhejiang,China)

机构地区：[1]中国人民解放军联勤保障部队923医院肾脏病科,广西南宁530021 [2]温州医科大学外科,浙江温州325000

出　　处：《西部医学》2019年第10期1554-1557,1563,共5页Medical Journal of West China

基　　金：国家自然科学基金项目(81402980)

摘　　要：目的研究并探讨氧化应激标志物晚期氧化蛋白产物(AOPP)在狼疮肾炎(LN)患者血清水平变化及其与疾病活动的相关性。方法选择2015年1月~2017年12月期间就诊于我院的80例狼疮肾炎患者和80例系统性红斑狼疮患者,分为狼疮肾炎组和单纯狼疮组,另选择同期在我院行健康体检且年龄、性别均与观察组匹配的80例健康志愿者,设置为对照组。比较狼疮肾炎组、单纯狼疮组与对照组的血肌酐、尿素氮、肾小球滤过率、24小时尿蛋白定量、血清AOPP水平;比较不同疾病活动度狼疮肾炎患者的血肌酐、尿素氮、肾小球滤过率、24小时尿蛋白定量、血清AOPP水平;对血肌酐、尿素氮、肾小球滤过率、24小时尿蛋白定量、血清AOPP与狼疮肾炎疾病活动度的相关性进行分析。结果狼疮肾炎组的血肌酐、尿素氮、24小时尿蛋白定量、血清AOPP均高于单纯狼疮组和对照组(P<0.05),其肾小球滤过率均低于单纯狼疮组和对照组(P<0.05);单纯狼疮组和对照组的血肌酐、尿素氮、肾小球滤过率、24小时尿蛋白定量比较无统计学意义(P>0.05),而血清AOPP水平高于对照组(P<0.05)。血肌酐、尿素氮、24小时尿蛋白定量、血清AOPP均与狼疮肾炎的发生呈正相关,肾小球滤过率与狼疮肾炎的发生呈负相关。轻度活动组、中度活动组、重度活动组的血肌酐、尿素氮、肾小球滤过率、24小时尿蛋白定量、血清AOPP比较均有统计学差异(P<0.05)。血肌酐、尿素氮、24小时尿蛋白、血清AOPP水平与狼疮肾炎疾病活动度均呈正相关,肾小球滤过率与狼疮肾炎的疾病活动度呈负相关。结论狼疮肾炎患者血清AOPP水平普遍出现异常增高现象,其疾病活动度越高,血清AOPP水平越高,临床上可将血清AOPP作为狼疮肾炎病情判断的辅助指标。Objective To investigate the changes of serum level of oxidative stress marker late oxidative protein product(advanced oxidation protein products, AOPP) in patients with lupus nephritis(lupus nephritis, LN) and its correlation with lupus nephritis disease activity. Methods From January 2015 to December 2017, 80 patients with lupus nephritis and 80 patients with systemic lupus erythematosus were selected as lupus nephritis group and simple lupus erythematosus group. Sex matched with the observation group of 80 healthy volunteers, set up as the control group. Serum creatinine, urea nitrogen and serum AOPP levels were measured in fasting peripheral venous blood and fresh morning urine from three groups. The serum creatinine and urea nitrogen in lupus nephritis group, simple lupus nephritis group and control group were compared, and the serum creatinine and urea nitrogen were compared between lupus nephritis group and control group. Glomerular filtration rate(GFR), 24 hour urinary protein quantification and serum AOPP level. Systemic lupus erythematosus disease activity index(systemic lupus erythematosus disease activity index, SLEDAI) was used to evaluate the disease activity of patients with lupus nephritis. The patients with lupus nephritis were divided into mild active group, moderate active group and severe active group. Serum creatinine, urea nitrogen, glomerular filtration rate, 24 hour urinary protein quantification, serum AOPP level, serum creatinine, urea nitrogen, glomerular filtration rate and 24 hour urine protein were compared in patients with lupus nephritis with different disease activity. The correlation between serum AOPP and lupus nephritis disease activity was analyzed. Results Serum creatinine, urea nitrogen, 24-hour urinary protein quantification, and serum AOPP in the lupus nephritis group were all higher than those in the lupus group and the control group(P<0.05), and their glomerular filtration rate was lower than those in the lupus group and the control group(P<0.05). Comparison of serum cre

关 键 词：狼疮肾炎 晚期氧化蛋白产物 疾病活动度 系统性红斑狼疮 

分 类 号：R593.242[医药卫生—内科学]