生物蛋白大环自组装及其功能化研究进展  

Progress in Self-Assembly and Functionalization of Protein-based Macrocycles

作　　者：徐强强[1] 龚翰林 尚洁 潘铁铮 葛岩 戚震辉 XU Qiang-qiang;GONG Han-lin;SHANG Jie;PAN Tie-zheng;GE Yan;QI Zhen-hui(Synergetic Innovation Center of Flexible Electronics and Healthcare Science of Shaanxi Province, Sino-German Joint Research Lab of Space Biomaterials and Translational Technology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China)

机构地区：[1]陕西省柔性电子与健康科学国际联合研究中心中德空间生物材料与技术转化联合实验室西北工业大学生命学院

出　　处：《高分子通报》2019年第10期119-129,共11页Polymer Bulletin

基　　金：陕西省重点研发计划(2019KW-031,2019KW-038)

摘　　要：主要介绍了生物蛋白大环自组装及其功能化研究的新进展,针对目前开发较为深入的蛋白大环结构特点、制备方法及其功能化探索等方面进行分析和评述.蛋白大环作为一类生物源高分子环状结构,其研究是高分子化学、大环化学的延伸与拓展.蛋白质大环结构为功能性高分子的构筑提供了全新的材料设计与研究思路.随着蛋白自组装行为的动力学和热力学机制得到更为深入的解析,操控蛋白自组装过程将变得更为娴熟.This review focuses on the recent progress of self-assembly and functionalization of protein-based macrocycles. Taking the most popular protein macrocycles as example, the structural features, fabrication strategies and functions of these well-explored protein-macrocycles were analyzed and compared. As a new kind of biogenic polymeric macrocycle, protein-macrocycles serve as the evolutionary product of biopolymer science and macrocyclic chemistry. The protein-macrocyclic structure provides a novel design material and construction platform for fabrication of functional polymers. With the accumulated knowledge of kinetics and thermodynamic behaviors, the manipulation of the self-assembly process of protein-macrocycles will become skilled.

关 键 词：蛋白大环 生物高分子 大环化学 自组装 

分 类 号：O641.3[理学—物理化学]