海南百岁老人C反应蛋白升高与慢性病的关系  

Relationship between elevated C-reactive protein and chronic diseases in centenarians in Hainan

作　　者：焦婷婷 韩秋霞 张冬[1] 张有才[3] 赵亚力 张福 栾复新 蔡广研[1] 陈香美[1] 朱晗玉[1] JIAO Tingling;HAN Qiuxia;ZHANG Dong;ZHANG Youcai;ZHAO Yali;ZHANG Fu;LU AN Fuxin;CAI Guangyan;CHEN Xiangmei;ZHU Hanyu(Department of Nephrology , Chinese PLA General Hospital, Chinese PLA Institute of Nephrology,State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Diseases , Beijing 100853, China;Grade 2019,Medical College of Nankai University , Tianjin 300071, China;Department of Nephrology ,Jiaozuo People' Hospital, Jiaozuo 454000, China;Central Laboratory , Hainan Branch of Chinese PLA General Hospital, Sanya 572000 , China;Department of Administration ,Hainan Branch of Chinese PLA General Hospital, Sanya 572000, China)

机构地区：[1]中国人民解放军总医院肾脏病科中国人民解放军肾脏病研究所肾脏疾病国家重点实验室国家慢性肾病临床医学研究中心北京肾脏疾病重点实验室,北京100853 [2]南开大学医学院,天津300071 [3]焦作市人民医院肾脏病科,河南焦作454000 [4]中国人民解放军总医院海南分院中心实验室,海南三亚572000 [5]中国人民解放军总医院海南分院管理科,海南三亚572000

出　　处：《中华实用诊断与治疗杂志》2019年第10期983-986,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(61671479);国家自然科学基金(61971441);国家重点研发项目(2016YFC1305500);海南省重点研发项目(ZDYF2016135);海南省重点研发项目(ZDYF2017095)

摘　　要：目的探讨海南百岁老人血清C反应蛋白(C-reactive protein, CRP)升高的影响因素及其与慢性疾病的关系。方法采用入户问卷调查方式对海南地区年龄≥100岁老人进行问卷调查,记录其一般人口学资料、体格检查及实验室检查结果,并根据CRP检测结果分为CRP升高组(CRP>8 mg/L)145例和CRP正常组(CPR≤8 mg/L)710例。比较2组一般资料、慢性病患病情况及实验室结果等,采用Pearson相关性分析CRP升高比率与慢性病种数的相关性。结果 CRP升高组血脂异常率(68.28%)低于CRP正常组(78.45%)(P<0.05),慢性肾脏病发生率(69.66%)高于CRP正常组(59.01%)(P<0.05),2组男性、汉族比率及贫血、糖尿病、高血压、高尿酸血症发生率比较差异均无统计学意义(P>0.05);CRP升高组免疫球蛋白A、免疫球蛋白G、补体C3、C4水平均高于CRP正常组(P<0.05),血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇、估算肾小球滤过率和血清白蛋白水平低于CRP正常组(P<0.05),空腹血糖、血尿酸、血红蛋白、血肌酐水平与CRP正常组比较差异均无统计学意义(P>0.05);CRP升高组未合并任何慢性疾病的比率为6.67%,合并1、2、3、4、5种慢性疾病比率分别为15.76%、16.83%、16.60%、21.15%、25.00%,CRP升高比率与慢性病种数呈明显正相关(r=0.934,P=0.006)。结论海南百岁老人CRP升高与患有慢性肾脏病、血脂异常及慢性病种数有关。Objective To analyze the influencing factors for C-reactive protein(CRP) elevation in Hainan centenarians and its relationship with chronic diseases. Methods The general demographic data, physical examination and laboratory examination results of the elderly aged ≥100 years old in Hainan were recorded by means of household questionnaire survey. According to the CRP level, 855 centenarians were divided into high CRP group(n=145, CRP >8 mg/L) and normal CRP group(n=710, CPR ≤8 mg/L). The general data, chronic diseases and laboratory results were compared between two groups.Pearson correlation analysis was used to analyze the correlation between the rates of patients with high CRP and the species of chronic diseases.Results The rate of dyslipidemia(68.28%)was lower and the incidence of chronic kidney disease(69.66%)was higher in high CRP group than that in normal CRP group(78.45%,59.01%)(P<0.05),and there were no significant differences in the percentages of males and Han population,and the incidences of anemia,diabetes,hypertension and hyperuricemia between two groups(P>0.05).The levels of immunoglobulin A,immunoglobulin G,complement C3 and complement C4 were significantly higher in high CRP group than those in normal CRP group(P<0.05),the levels of serum total cholesterol,triacylglycerol,high-density lipoprotein cholesterol,estimated glomerular filtration rate and albumin were significantly lower than those in normal CRP group(P<0.05),and there were no significant differences in fasting plasma glucose,uric acid,hemoglobin and serum creatinine between two groups(P>0.05).The incidences of complications of 0,1,2,3,4 and 5 kinds were 25.00%,6.67%,15.76%,16.83%,16.60% and 21.15%in high CRP group.The rate of CRP increased was positively correlated with the species of chronic diseases(r=0.934,P=0.006).Conclusion The elevated CRP in Hainan centenarians is correlated with chronic kidney disease,dyslipidemia and species of chronic diseases.

关 键 词：慢性病 C反应蛋白 百岁老人 

分 类 号：R446.1[医药卫生—诊断学]