鲑鱼降钙素对胸腰椎脊柱骨折术后Ⅰ型胶原氨基端延长肽、Ⅰ型胶原C端肽β降解产物的作用  

Effect of Calcitonin on the Amino Terminal Elongation Peptide of Type Ⅰ Collagen and Type Ⅰ Collagen C-Terminal Peptide β Degradation Products after Thoracolumbar Spine Fracture

作　　者：张中平[1] 赵毅[1] 曹华佗 王飞[2] 杨明智[1] ZHANG Zhong-ping;ZHAO Yi;CAO Hua-tuo;WANG Fei;YANG Ming-zhi(Department of orthopedics,Yan'an People's Hospital,Yan'an,Shaanxi,716000,China;Spinal surgery,Affiliated Hospital of Yan'an University,Yan'an,Shaanxi,716000,China)

机构地区：[1]延安市人民医院,骨科一病区,陕西延安716000 [2]延安大学附属医院脊柱外科,陕西延安716000

出　　处：《现代生物医学进展》2019年第18期3550-3553,3558,共5页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目（2008K14-1）

摘　　要：目的:探讨鲑鱼降钙素对胸腰椎脊柱骨折术后Ⅰ型胶原氨基端延长肽、Ⅰ型胶原C端肽β降解产物的作用。方法:选择2014年3月至2016年5月我院收治的胸腰椎脊柱骨折患者80例,将其随机分为观察组和对照组,每组40例。两组均采用微创经皮椎弓根螺钉内固定术,对照组术后给予常规治疗,观察组术后给予鲑鱼降钙素治疗。比较两组患者治疗前后的骨密度、Ⅰ型胶原氨基端延长肽、Ⅰ型胶原C端肽β降解产物、视觉模拟疼痛评分(VAS)评分、Oswestry功能障碍指数评分(ODI)评分、Harris评分的变化、骨折愈合时间及不良反应的发生情况。结果:治疗后,观察组患者骨密度及Harris评分明显高于对照组(P<0.05),Ⅰ型胶原氨基端延长肽、Ⅰ型胶原C端肽β降解产物、VAS评分和ODI评分均低于对照组(P<0.05);观察组患者骨折愈合时间明显短于对照组(P<0.05),不良反应发生率(7.50%)较对照组(10.00%)比较无显著性差异(P>0.05)。结论:鲑鱼降钙素用于胸腰椎脊柱骨折术后可有效改善患者骨密度,促进骨折愈合且不会增加不良反应。Objective: To study the effect of calcitonin on the amino terminal elongation peptide of type Ⅰ collagen and type Ⅰ collagen C-terminal peptide β degradation products was applied after thoracolumbar spine fracture. Methods: 80 patients with thoracolumbar spine fracture from March 2014 to May 2016 in our hospital were randomly divided into the observation group and the control group with 40 cases in each group. They were treated with minimally invasive percutaneous pedicle screw fixation, and the control group was given routine treatment after operation, and the observation group was given salmon calcitonin treatment after operation. The bone mineral density, amino terminal elongation peptide of type Ⅰ collagen, type Ⅰ collagen C-terminal peptide βdegradation products, visual analog pain score(VAS) score, Oswestry disability index score(ODI) score, Harris score fracture healing time and incidence of adverse reactions were compared between two groups. Results: After treatment, the bone density and Harris score in the observation group was significantly higher than those of the control group(P<0.05);while the amino terminal elongation peptide of type Ⅰ collagen, type Ⅰ collagen C-terminal peptide β degradation products, VAS score and ODI score were lower than those of the control group(P<0.05);the fracture healing time in the observation group was shorter that of the control group(P<0.05);the incidence of adverse reactions(7.50%) showed no significant difference compared with that of the control group(10.00%)(P>0.05). Conclusion: The use of salmon calcitonin after thoracolumbar spine fracture can effectively improve the bone density of patients, promote the healing time of fracture factors With high safety.

关 键 词：胸腰椎脊柱骨折 鲑鱼降钙素 Ⅰ型胶原氨基端延长肽 Ⅰ型胶原C端肽β降解产物 

分 类 号：R683[医药卫生—骨科学]