过敏性紫癜性肾炎肾组织中KIM-1的表达与临床意义  

Expression and Clinical Significance of KIM-1 in the Henoch Schonlein Purpura Nephritis

作　　者：王德元 冯学梅 谢海林 祁秉民 李学梅[3] WANG De-yuan;FENG Xue-mei;XIE Hai-lin;QI Bing-min;LI Xue-mei(Laboratory Medicine Department,Tibetan Hospital ofQinghai Province,Xining,Qinghai,810007,China;Laboratory Medicine Department,Qinghai Fifth People's Hospital,Xining,Qinghai,810007,China;Laboratory Medicine Department,Qinghai University Affiliated Hospital,Xining,Qinghai,810001,China)

机构地区：[1]青海省藏医院检验科,青海西宁810007 [2]青海省第五人民医院检验科,青海西宁810007 [3]青海大学附属医院检验科,青海西宁810001

出　　处：《现代生物医学进展》2019年第17期3384-3388,共5页Progress in Modern Biomedicine

基　　金：青海省科技厅基金项目(96301716)

摘　　要：目的:探讨过敏性紫癜性肾炎肾组织中肾损伤分子1(kidney injury molecule 1,KIM-1)的表达与临床意义。方法:选择2015年4月到2018年1月在我院诊治的过敏性紫癜性肾炎患者150例作为研究对象,采用免疫组化法检测患者肾组织中KIM-1表达,采用半定量评分系统进行肾脏病理损害评分,并对二者进行相关性分析。结果:肾炎组织与肾旁组织的KIM-1相对表达量分别为(9.28±1.38)和(2.74±1.30),肾炎组织中KIM-1的表达显著高于肾旁组织(P=0.000);肾炎组织的毛细血管外肾小球活动、系膜增殖、内皮增殖、肾间质炎症、肾小球慢性化、肾小管间质慢性化指数评分均显著高于肾旁组织(P<0.05);肾组织KIM-1表达量与肾小球慢性化指数、肾间质炎症指数、肾小管间质慢性化指数均呈显著正相关性(P<0.05)。结论:过敏性紫癜性肾炎组织中KIM-1呈高表达,可能作为评估肾脏病理病变程度的参考指标。Objective: To investigate the expression and clinical significance of kidney injury molecule 1(KIM-1) in the renal tissue of Henoch-Schonlein purpura nephritis(HSPN). Methods: 150 patients with HSPN who were treated in our hospital from April 2015 to January 2018 were selected as the research objects. The expression of KIM-1 in the renal tissue was detected by immunohistochemical method. The renal pathological damage score was evaluated by semi-quantitative scoring system. Results: The relative expression of KIM-1 in the nephritic tissue and paranephritic tissue were(9.28±1.38) and(2.74±1.30), respectively. The expression of KIM-1 in the nephritic tissue was significantly higher than that in the paranephritic tissue(P=0.000). The scores of extracapillary glomerular activity,mesangial proliferation, endothelial proliferation, interstitial inflammation, glomerular chronicity and tubulointerstitial chronicity index in the nephritic tissue were significantly higher than those in the paranephritic tissue(P<0.05). The expression of KIM-1 was positively correlated with the glomerular chronic index, renal interstitial inflammatory index and tubulointerstitial chronic index(P<0.05). Conclusion:KIM-1 is highly expressed in the HSPN tissue, which may serve as a reference index for evaluating the degree of renal pathological changes.

关 键 词：人肾损伤分子1 过敏性紫癜性肾炎 肾炎组织 相关性 

分 类 号：R692.34[医药卫生—泌尿科学]